4yih
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Crystal structure of human cytosolic 5'(3')-deoxyribonucleotidase in complex with the inhibitor PB-PVU== |
| - | + | <StructureSection load='4yih' size='340' side='right' caption='[[4yih]], [[Resolution|resolution]] 1.82Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4yih]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YIH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YIH FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2O2:1-{2-DEOXY-3,5-O-[PHENYL(PHOSPHONO)METHYLIDENE]-BETA-D-THREO-PENTOFURANOSYL}-5-[(E)-2-PHOSPHONOETHENYL]PYRIMIDINE-2,4(1H,3H)-DIONE'>2O2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yih OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yih RCSB], [http://www.ebi.ac.uk/pdbsum/4yih PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| + | [[http://www.uniprot.org/uniprot/NT5C_HUMAN NT5C_HUMAN]] Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Brynda, J]] | [[Category: Brynda, J]] | ||
[[Category: Pachl, P]] | [[Category: Pachl, P]] | ||
[[Category: Rezacova, P]] | [[Category: Rezacova, P]] | ||
| + | [[Category: 5'-nucleotidase]] | ||
| + | [[Category: Dephosphorylation]] | ||
| + | [[Category: Had-like]] | ||
| + | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
| + | [[Category: Mitochondria]] | ||
| + | [[Category: Phosphorylation]] | ||
Revision as of 11:20, 9 September 2015
Crystal structure of human cytosolic 5'(3')-deoxyribonucleotidase in complex with the inhibitor PB-PVU
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