1lk9

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|PDB= 1lk9 |SIZE=350|CAPTION= <scene name='initialview01'>1lk9</scene>, resolution 1.53&Aring;
|PDB= 1lk9 |SIZE=350|CAPTION= <scene name='initialview01'>1lk9</scene>, resolution 1.53&Aring;
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5'-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene> and <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID'>EPE</scene>
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5&#39;-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene> and <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID'>EPE</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Alliin_lyase Alliin lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.4.1.4 4.4.1.4]
|ACTIVITY= [http://en.wikipedia.org/wiki/Alliin_lyase Alliin lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.4.1.4 4.4.1.4]
|GENE=
|GENE=
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[[Category: plp type 1]]
[[Category: plp type 1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:31:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 12:38:10 2008''

Revision as of 10:38, 23 March 2008

Image:1lk9.gif


PDB ID 1lk9

Drag the structure with the mouse to rotate
, resolution 1.53Å
Ligands: , , , and
Activity: Alliin lyase, with EC number 4.4.1.4
Coordinates: save as pdb, mmCIF, xml



The Three-dimensional Structure of Alliinase from Garlic


Overview

Despite the fact that many cultures around the world value and utilize garlic as a fundamental component of their cuisine as well as of their medicine cabinets, relatively little is known about the plant's protein configuration that is responsible for the specific properties of garlic. Here, we report the three-dimensional structure of the garlic enzyme alliinase at 1.5 A resolution. Alliinase constitutes the major protein component in garlic bulbs, and it is able to cleave carbon-sulfur bonds. The active enzyme is a pyridoxal-5'-phosphate-dependent homodimeric glycoprotein and belongs to the class I family of pyridoxal-5'-phosphate-dependent enzymes. In addition, it contains a novel epidermal growth factor-like domain that makes it unique among all pyridoxal-5'-phosphate-dependent enzymes.

About this Structure

1LK9 is a Single protein structure of sequence from Allium sativum. Full crystallographic information is available from OCA.

Reference

The active principle of garlic at atomic resolution., Kuettner EB, Hilgenfeld R, Weiss MS, J Biol Chem. 2002 Nov 29;277(48):46402-7. Epub 2002 Sep 15. PMID:12235163

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