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1chl
From Proteopedia
(Difference between revisions)
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<StructureSection load='1chl' size='340' side='right' caption='[[1chl]], [[NMR_Ensembles_of_Models | 7 NMR models]]' scene=''> | <StructureSection load='1chl' size='340' side='right' caption='[[1chl]], [[NMR_Ensembles_of_Models | 7 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1chl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1chl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Egyptian_scorpion Egyptian scorpion]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CHL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CHL FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1chl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1chl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1chl RCSB], [http://www.ebi.ac.uk/pdbsum/1chl PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1chl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1chl OCA], [http://pdbe.org/1chl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1chl RCSB], [http://www.ebi.ac.uk/pdbsum/1chl PDBsum]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/ | + | [[http://www.uniprot.org/uniprot/CTXL_LEIQU CTXL_LEIQU]] This toxin binds to the surface of glioma cells, and inhibits their proliferation without having effects on normal brain cells. In this context, this toxin has been described as a chloride channel inhibitor (probably ClC-3/CLCN3) by causing its internalization via caveolae (PubMed:16520829). It has also been described to selectively interact with MMP2 (in complex with MT1-MMP (MMP14) and TIMP2), to inhibit its enzymatic activity and to decrease its presence at the cell surface (PubMed:12454020).<ref>PMID:12454020</ref> <ref>PMID:16520829</ref> <ref>PMID:8383429</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 1chl" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Egyptian scorpion]] |
[[Category: Lippens, G]] | [[Category: Lippens, G]] | ||
[[Category: Najib, J]] | [[Category: Najib, J]] | ||
Revision as of 21:31, 9 September 2015
NMR SEQUENTIAL ASSIGNMENTS AND SOLUTION STRUCTURE OF CHLOROTOXIN, A SMALL SCORPION TOXIN THAT BLOCKS CHLORIDE CHANNELS
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