1m7b

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|PDB= 1m7b |SIZE=350|CAPTION= <scene name='initialview01'>1m7b</scene>, resolution 2.00&Aring;
|PDB= 1m7b |SIZE=350|CAPTION= <scene name='initialview01'>1m7b</scene>, resolution 2.00&Aring;
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=GTP:GUANOSINE-5'-TRIPHOSPHATE'>GTP</scene>
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=GTP:GUANOSINE-5&#39;-TRIPHOSPHATE'>GTP</scene>
|ACTIVITY=
|ACTIVITY=
|GENE= Rnd3 (amino acids 19-200) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
|GENE= Rnd3 (amino acids 19-200) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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[[Category: small gtpase]]
[[Category: small gtpase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:39:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 12:43:35 2008''

Revision as of 10:43, 23 March 2008

Image:1m7b.jpg


PDB ID 1m7b

Drag the structure with the mouse to rotate
, resolution 2.00Å
Ligands: and
Gene: Rnd3 (amino acids 19-200) (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



Crystal structure of Rnd3/RhoE: functional implications


Overview

The Rnd proteins constitute an exceptional subfamily within the Rho GTPase family. They possess extended chains at both termini and four prominent amino acid deviations causing GTPase deficiency. Herein, we report the crystal structure of the Rnd3/RhoE G-domain (amino acids 19-200) at 2.0 A resolution. This is the first GTP-structure of a Rho family member which reveals a similar fold but striking differences from RhoA concerning (i) GTPase center, (ii) charge distribution at several surface areas, (iii) C3-transferase binding site and (iv) interacting interfaces towards RhoA regulators and effectors.

About this Structure

1M7B is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of Rnd3/RhoE: functional implications., Fiegen D, Blumenstein L, Stege P, Vetter IR, Ahmadian MR, FEBS Lett. 2002 Aug 14;525(1-3):100-4. PMID:12163169

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