1n1h

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|PDB= 1n1h |SIZE=350|CAPTION= <scene name='initialview01'>1n1h</scene>, resolution 2.80&Aring;
|PDB= 1n1h |SIZE=350|CAPTION= <scene name='initialview01'>1n1h</scene>, resolution 2.80&Aring;
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=G7M:N7-METHYL-GUANOSINE-5'-MONOPHOSPHATE'>G7M</scene>, <scene name='pdbligand=GDP:GUANOSINE-5'-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=CH1:3'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE'>CH1</scene> and <scene name='pdbligand=GH3:3'-DEOXY-GUANOSINE-5'-TRIPHOSPHATE'>GH3</scene>
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|LIGAND= <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=G7M:N7-METHYL-GUANOSINE-5&#39;-MONOPHOSPHATE'>G7M</scene>, <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=CH1:3&#39;-DEOXY-CYTIDINE-5&#39;-TRIPHOSPHATE'>CH1</scene> and <scene name='pdbligand=GH3:3&#39;-DEOXY-GUANOSINE-5&#39;-TRIPHOSPHATE'>GH3</scene>
|ACTIVITY=
|ACTIVITY=
|GENE= L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10886 Mammalian orthoreovirus 3])
|GENE= L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10886 Mammalian orthoreovirus 3])
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[[Category: right hand configuration]]
[[Category: right hand configuration]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:50:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 12:50:30 2008''

Revision as of 10:50, 23 March 2008

Image:1n1h.gif


PDB ID 1n1h

Drag the structure with the mouse to rotate
, resolution 2.80Å
Ligands: , , , and
Gene: L1 (Mammalian orthoreovirus 3)
Coordinates: save as pdb, mmCIF, xml



Initiation complex of polymerase lambda3 from reovirus


Overview

The reovirus polymerase and those of other dsRNA viruses function within the confines of a protein capsid to transcribe the tightly packed dsRNA genome segments. The crystal structure of the reovirus polymerase, lambda3, determined at 2.5 A resolution, shows a fingers-palm-thumb core, similar to those of other viral polymerases, surrounded by major N- and C-terminal elaborations, which create a cage-like structure, with four channels leading to the catalytic site. This "caged" polymerase has allowed us to visualize the results of several rounds of RNA polymerization directly in the crystals. A 5' cap binding site on the surface of lambda3 suggests a template retention mechanism by which attachment of the 5' end of the plus-sense strand facilitates insertion of the 3' end of the minus-sense strand into the template channel.

About this Structure

1N1H is a Single protein structure of sequence from Mammalian orthoreovirus 3. Full crystallographic information is available from OCA.

Reference

RNA synthesis in a cage--structural studies of reovirus polymerase lambda3., Tao Y, Farsetta DL, Nibert ML, Harrison SC, Cell. 2002 Nov 27;111(5):733-45. PMID:12464184

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