1odv
From Proteopedia
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|PDB= 1odv |SIZE=350|CAPTION= <scene name='initialview01'>1odv</scene>, resolution 1.14Å | |PDB= 1odv |SIZE=350|CAPTION= <scene name='initialview01'>1odv</scene>, resolution 1.14Å | ||
|SITE= <scene name='pdbsite=AC1:Hc4+Binding+Site+For+Chain+B'>AC1</scene> | |SITE= <scene name='pdbsite=AC1:Hc4+Binding+Site+For+Chain+B'>AC1</scene> | ||
| - | |LIGAND= <scene name='pdbligand=HC4:4 | + | |LIGAND= <scene name='pdbligand=HC4:4'-HYDROXYCINNAMIC ACID'>HC4</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
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[[Category: signalling]] | [[Category: signalling]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 13:02:57 2008'' |
Revision as of 11:03, 23 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
PHOTOACTIVE YELLOW PROTEIN 1-25 DELETION MUTANT
Overview
PAS (PER-ARNT-SIM) domains are a family of sensor protein domains involved in signal transduction in a wide range of organisms. Recent structural studies have revealed that these domains contain a structurally conserved alpha/beta-fold, whereas almost no conservation is observed at the amino acid sequence level. The photoactive yellow protein, a bacterial light sensor, has been proposed as the PAS structural prototype yet contains an N-terminal helix-turn-helix motif not found in other PAS domains. Here we describe the atomic resolution structure of a photoactive yellow protein deletion mutant lacking this motif, revealing that the PAS domain is indeed able to fold independently and is not affected by the removal of these residues. Computer simulations of currently known PAS domain structures reveal that these domains are not only structurally conserved but are also similar in their conformational flexibilities. The observed motions point to a possible common mechanism for communicating ligand binding/activation to downstream transducer proteins.
About this Structure
1ODV is a Single protein structure of sequence from Halorhodospira halophila. Full crystallographic information is available from OCA.
Reference
PAS domains. Common structure and common flexibility., Vreede J, van der Horst MA, Hellingwerf KJ, Crielaard W, van Aalten DM, J Biol Chem. 2003 May 16;278(20):18434-9. Epub 2003 Mar 14. PMID:12639952
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