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2jkg

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Revision as of 03:01, 10 September 2015

PLASMODIUM FALCIPARUM PROFILIN

Structural highlights

2jkg is a 2 chain structure with sequence from Plafa. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Related:	2jkf
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum

Function

[PROF_PLAF7] Essential for the invasive blood stages of the parasite. Binds to proline rich sequences in various regulatory formin-like proteins and also to membrane phospholipids. Binds to actin and affects the structure of the cytoskeleton. Weakly sequesters actin monomers (By similarity).[UniProtKB:P86294]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Profilins are key regulators of actin dynamics. They sequester actin monomers, forming a pool for rapid polymer formation stimulated by proteins such as formins. Apicomplexan parasites utilize a highly specialized microfilament system for motility and host cell invasion. Their genomes encode only a small number of divergent actin regulators. We present the first crystal structure of an apicomplexan profilin, that of the malaria parasite Plasmodium falciparum, alone and in complex with a polyproline ligand peptide. The most striking feature of Plasmodium profilin is a unique minidomain consisting of a large beta-hairpin extension common to all apicomplexan parasites, and an acidic loop specific for Plasmodium species. Reverse genetics in the rodent malaria model, Plasmodium berghei, suggests that profilin is essential for the invasive blood stages of the parasite. Together, our data establish the structural basis for understanding the functions of profilin in the malaria parasite.

Structural basis for parasite-specific functions of the divergent profilin of Plasmodium falciparum.,Kursula I, Kursula P, Ganter M, Panjikar S, Matuschewski K, Schuler H Structure. 2008 Nov 12;16(11):1638-48. PMID:19000816^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Kursula I, Kursula P, Ganter M, Panjikar S, Matuschewski K, Schuler H. Structural basis for parasite-specific functions of the divergent profilin of Plasmodium falciparum. Structure. 2008 Nov 12;16(11):1638-48. PMID:19000816 doi:10.1016/j.str.2008.09.008

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2jkg"

@@ Line 2: / Line 2: @@
 <StructureSection load='2jkg' size='340' side='right' caption='[[2jkg]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2jkg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JKG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JKG FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2jkg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JKG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JKG FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jkf|2jkf]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jkg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jkg RCSB], [http://www.ebi.ac.uk/pdbsum/2jkg PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jkg OCA], [http://pdbe.org/2jkg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jkg RCSB], [http://www.ebi.ac.uk/pdbsum/2jkg PDBsum]</span></td></tr>
 </table>
 == Function ==
@@ Line 27: / Line 27: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 2jkg" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Profilin|Profilin]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Plasmodium falciparum]]
+[[Category: Plafa]]
 [[Category: Ganter, M]]
 [[Category: Kursula, I]]

2jkg

From Proteopedia

Revision as of 03:01, 10 September 2015

PLASMODIUM FALCIPARUM PROFILIN

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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