1utr
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 1utr |SIZE=350|CAPTION= <scene name='initialview01'>1utr</scene> | |PDB= 1utr |SIZE=350|CAPTION= <scene name='initialview01'>1utr</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=PCB:4,4 | + | |LIGAND= <scene name='pdbligand=PCB:4,4'-BIS([H]METHYLSULFONYL)-2,2',5,5'-TETRACHLOROBIPHENYL'>PCB</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= POTENTIAL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]) | |GENE= POTENTIAL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]) | ||
| Line 34: | Line 34: | ||
[[Category: uteroglobin]] | [[Category: uteroglobin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 13:54:46 2008'' |
Revision as of 11:54, 23 March 2008
| |||||||
| Ligands: | |||||||
| Gene: | POTENTIAL (Rattus norvegicus) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
UTEROGLOBIN-PCB COMPLEX (REDUCED FORM)
Overview
Metabolites of polychlorinated biphenyls (PCBs) bind with high affinity to uteroglobin, a small homodimeric protein that also binds progesterone. We present the solution structure of the reduced form of rat uteroglobin in complex with a PCB methylsulphone, (MeSO2)2-TCB. The structure reveals the molecular basis for the accumulation of (MeSO2)2-TCB by uteroglobin. The structure also shows how ligand binding and release might be controlled by reduction/oxidation of two intermolecular disulphide bonds. Breakage of these bonds induces a local unfolding of the N- and C-termini and a separation of helices creating a channel into the binding site. These effects make the ligand binding cavity readily accessible to entry of the ligand.
About this Structure
1UTR is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Solution structure of a mammalian PCB-binding protein in complex with a PCB., Hard T, Barnes HJ, Larsson C, Gustafsson JA, Lund J, Nat Struct Biol. 1995 Nov;2(11):983-9. PMID:7583672
Page seeded by OCA on Sun Mar 23 13:54:46 2008
