1uw1

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|PDB= 1uw1 |SIZE=350|CAPTION= <scene name='initialview01'>1uw1</scene>, resolution 1.94&Aring;
|PDB= 1uw1 |SIZE=350|CAPTION= <scene name='initialview01'>1uw1</scene>, resolution 1.94&Aring;
|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+A'>AC1</scene>
|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+A'>AC1</scene>
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=ADP:ADENOSINE-5'-DIPHOSPHATE'>ADP</scene>
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>
|ACTIVITY=
|ACTIVITY=
|GENE=
|GENE=
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[[Category: nucleotide binding protein]]
[[Category: nucleotide binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:37:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 13:55:20 2008''

Revision as of 11:55, 23 March 2008

Image:1uw1.jpg


PDB ID 1uw1

Drag the structure with the mouse to rotate
, resolution 1.94Å
Sites:
Ligands: and
Coordinates: save as pdb, mmCIF, xml



A NOVEL ADP- AND ZINC-BINDING FOLD FROM FUNCTION-DIRECTED IN VITRO EVOLUTION


Overview

A great challenge to biologists is to create proteins with novel folds and tailored functions. As an alternative to de novo protein design, we investigated the structure of a randomly generated protein targeted to bind ATP. The crystal structure reveals a novel alpha/beta fold bound to its ligand, representing both the first protein structure derived from in vitro evolution and the first nucleotide-binding protein stabilized by a zinc ion.

About this Structure

1UW1 is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.

Reference

A novel ADP- and zinc-binding fold from function-directed in vitro evolution., Lo Surdo P, Walsh MA, Sollazzo M, Nat Struct Mol Biol. 2004 Apr;11(4):382-3. Epub 2004 Mar 14. PMID:15024384 [[Category: ]]

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