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2hc8

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Revision as of 09:10, 10 September 2015

Structure of the A. fulgidus CopA A-domain

Structural highlights

2hc8 is a 1 chain structure with sequence from Arcfl. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum

Function

[COPA_ARCFU] Probably involved in copper and silver export.^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Copper homeostasis is maintained in part by membrane-bound P(1B)-type ATPases that are found in all organisms and drive the transport of this essential, yet toxic, metal ion across cellular membranes. CopA from Archaeoglobus fulgidus is a hyperthermophilic member of this ATPase subfamily and is homologous to the human Wilson and Menkes disease ATPases. To gain insight into Cu(+)-ATPase function, the structure of the CopA actuator domain (A-domain) was determined to 1.65 A resolution. The CopA A-domain functions to couple ATP hydrolysis in the ATP binding domain (ATPBD) with structural rearrangements of critical transmembrane segments. Its fold is quite similar to that of the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA1) A-domain, with the exception of an external loop region. On the basis of sequence and structural comparisons, specific residues that probably interact with the CopA ATPBD have been identified. Comparisons to the Wilson and Menkes disease A-domains reveal the presence of an additional loop that may be associated with regulatory functions in eukaryotic Cu(+)-ATPases. Finally, several mutations in the Wilson and Menkes disease ATPases occur in the A-domain, and their likely effects on function can be inferred from the CopA A-domain structure.

Structure of the actuator domain from the Archaeoglobus fulgidus Cu(+)-ATPase.,Sazinsky MH, Agarwal S, Arguello JM, Rosenzweig AC Biochemistry. 2006 Aug 22;45(33):9949-55. PMID:16906753^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Mandal AK, Cheung WD, Arguello JM. Characterization of a thermophilic P-type Ag+/Cu+-ATPase from the extremophile Archaeoglobus fulgidus. J Biol Chem. 2002 Mar 1;277(9):7201-8. Epub 2001 Dec 26. PMID:11756450 doi:10.1074/jbc.M109964200
↑ Sazinsky MH, Agarwal S, Arguello JM, Rosenzweig AC. Structure of the actuator domain from the Archaeoglobus fulgidus Cu(+)-ATPase. Biochemistry. 2006 Aug 22;45(33):9949-55. PMID:16906753 doi:10.1021/bi0610045

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2hc8"

@@ Line 2: / Line 2: @@
 <StructureSection load='2hc8' size='340' side='right' caption='[[2hc8]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2hc8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HC8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HC8 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2hc8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arcfl Arcfl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HC8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HC8 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hc8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hc8 RCSB], [http://www.ebi.ac.uk/pdbsum/2hc8 PDBsum]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hc8 OCA], [http://pdbe.org/2hc8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hc8 RCSB], [http://www.ebi.ac.uk/pdbsum/2hc8 PDBsum]</span></td></tr>
 </table>
+== Function ==
+[[http://www.uniprot.org/uniprot/COPA_ARCFU COPA_ARCFU]] Probably involved in copper and silver export.<ref>PMID:11756450</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 23: / Line 25: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 2hc8" style="background-color:#fffaf0;"></div>
 ==See Also==
@@ Line 30: / Line 33: @@
 __TOC__
 </StructureSection>
-[[Category: Archaeoglobus fulgidus]]
+[[Category: Arcfl]]
 [[Category: Agawal, S]]
 [[Category: Arguello, J M]]

2hc8

From Proteopedia

Revision as of 09:10, 10 September 2015

Structure of the A. fulgidus CopA A-domain

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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