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1ymf

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|PDB= 1ymf |SIZE=350|CAPTION= <scene name='initialview01'>1ymf</scene>, resolution 2.6&Aring;
|PDB= 1ymf |SIZE=350|CAPTION= <scene name='initialview01'>1ymf</scene>, resolution 2.6&Aring;
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|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5'-DIPHOSPHATE'>ADP</scene>
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|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>
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[[Category: yellow fever virus]]
[[Category: yellow fever virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:24:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 14:22:23 2008''

Revision as of 12:22, 23 March 2008

Image:1ymf.gif


PDB ID 1ymf

Drag the structure with the mouse to rotate
, resolution 2.6Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



crystal structure of yellow fever virus NS3 helicase complexed with ADP


Overview

Yellow fever virus (YFV), a member of the Flavivirus genus, has a plus-sense RNA genome encoding a single polyprotein. Viral protein NS3 includes a protease and a helicase that are essential to virus replication and to RNA capping. The 1.8-A crystal structure of the helicase region of the YFV NS3 protein includes residues 187 to 623. Two familiar helicase domains bind nucleotide in a triphosphate pocket without base recognition, providing a site for nonspecific hydrolysis of nucleoside triphosphates and RNA triphosphate. The third, C-terminal domain has a unique structure and is proposed to function in RNA and protein recognition. The organization of the three domains indicates that cleavage of the viral polyprotein NS3-NS4A junction occurs in trans.

About this Structure

1YMF is a Single protein structure of sequence from Yellow fever virus. Full crystallographic information is available from OCA.

Reference

Structure of the Flavivirus helicase: implications for catalytic activity, protein interactions, and proteolytic processing., Wu J, Bera AK, Kuhn RJ, Smith JL, J Virol. 2005 Aug;79(16):10268-77. PMID:16051820

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