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1zsv
From Proteopedia
(Difference between revisions)
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<StructureSection load='1zsv' size='340' side='right' caption='[[1zsv]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='1zsv' size='340' side='right' caption='[[1zsv]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1zsv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1zsv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZSV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZSV FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LTB4DH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LTB4DH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zsv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zsv RCSB], [http://www.ebi.ac.uk/pdbsum/1zsv PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zsv OCA], [http://pdbe.org/1zsv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zsv RCSB], [http://www.ebi.ac.uk/pdbsum/1zsv PDBsum]</span></td></tr> |
</table> | </table> | ||
| - | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/LTB4D_HUMAN LTB4D_HUMAN]] Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha (By similarity). Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Human]] |
[[Category: Arrowsmith, C]] | [[Category: Arrowsmith, C]] | ||
[[Category: Delft, F von]] | [[Category: Delft, F von]] | ||
| Line 35: | Line 33: | ||
[[Category: Sundstrom, M]] | [[Category: Sundstrom, M]] | ||
[[Category: Turnbull, A P]] | [[Category: Turnbull, A P]] | ||
| - | [[Category: Human]] | ||
[[Category: Leukotriene b4]] | [[Category: Leukotriene b4]] | ||
[[Category: Medium-chain dehydrogenase/reductase family]] | [[Category: Medium-chain dehydrogenase/reductase family]] | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
Revision as of 09:37, 10 September 2015
Crystal structure of human NADP-dependent leukotriene B4 12-hydroxydehydrogenase
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