2k9d

From Proteopedia

(Difference between revisions)

Revision as of 10:41, 10 September 2015

Solution structure of the domain X of measle phosphoprotein

Structural highlights

2k9d is a 1 chain structure with sequence from Cell-associated subacute sclerosing panencephalitis. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	P/V (Cell-associated subacute sclerosing panencephalitis)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum

Function

[PHOSP_MEASE] Essential component of the RNA polymerase and the nascent chain assembly complex. Also required during RNA synthesis.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

In this paper we investigate the interaction between the C-terminal domains of the measles virus phosphoprotein (XD) and nucleoprotein (N(TAIL)) by using nuclear magnetic resonance chemical shift perturbation experiments. Using both N(TAIL) constructs and peptides, we show that contrary to the conserved Box2 region (N(489-506)), the C-terminal region of N(TAIL) (N(513-525)) does not directly interact with XD, and yet affects binding to XD. We tentatively propose a model where the C-terminus of N(TAIL) would stabilize the N(TAIL)-XD complex either via a functional coupling with N(489-506) or by reducing the entropic penalty associated to the binding-coupled-to-folding process.

Interaction between the C-terminal domains of N and P proteins of measles virus investigated by NMR.,Bernard C, Gely S, Bourhis JM, Morelli X, Longhi S, Darbon H FEBS Lett. 2009 Apr 2;583(7):1084-9. Epub 2009 Mar 9. PMID:19275899^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Bernard C, Gely S, Bourhis JM, Morelli X, Longhi S, Darbon H. Interaction between the C-terminal domains of N and P proteins of measles virus investigated by NMR. FEBS Lett. 2009 Apr 2;583(7):1084-9. Epub 2009 Mar 9. PMID:19275899 doi:10.1016/j.febslet.2009.03.004

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2k9d"

@@ Line 2: / Line 2: @@
 <StructureSection load='2k9d' size='340' side='right' caption='[[2k9d]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2k9d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Measles_virus Measles virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2K9D FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2k9d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cell-associated_subacute_sclerosing_panencephalitis Cell-associated subacute sclerosing panencephalitis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2K9D FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">P/V ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11234 Measles virus])</td></tr>
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">P/V ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11234 Cell-associated subacute sclerosing panencephalitis])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k9d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2k9d RCSB], [http://www.ebi.ac.uk/pdbsum/2k9d PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k9d OCA], [http://pdbe.org/2k9d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2k9d RCSB], [http://www.ebi.ac.uk/pdbsum/2k9d PDBsum]</span></td></tr>
 </table>
 == Function ==
@@ Line 26: / Line 26: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 2k9d" style="background-color:#fffaf0;"></div>
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Measles virus]]
+[[Category: Cell-associated subacute sclerosing panencephalitis]]
 [[Category: Bernard, C]]
 [[Category: Bourhis, J M]]

2k9d

From Proteopedia

Revision as of 10:41, 10 September 2015

Solution structure of the domain X of measle phosphoprotein

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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