This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2e4u
From Proteopedia
(Difference between revisions)
| Line 2: | Line 2: | ||
<StructureSection load='2e4u' size='340' side='right' caption='[[2e4u]], [[Resolution|resolution]] 2.35Å' scene=''> | <StructureSection load='2e4u' size='340' side='right' caption='[[2e4u]], [[Resolution|resolution]] 2.35Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2e4u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2e4u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E4U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E4U FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2e4v|2e4v]], [[2e4w|2e4w]], [[2e4x|2e4x]], [[2e4y|2e4y]], [[2e4z|2e4z]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2e4v|2e4v]], [[2e4w|2e4w]], [[2e4x|2e4x]], [[2e4y|2e4y]], [[2e4z|2e4z]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e4u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e4u RCSB], [http://www.ebi.ac.uk/pdbsum/2e4u PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e4u OCA], [http://pdbe.org/2e4u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2e4u RCSB], [http://www.ebi.ac.uk/pdbsum/2e4u PDBsum]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GRM3_RAT GRM3_RAT]] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 25: | Line 27: | ||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2e4u" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| Line 32: | Line 35: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Buffalo rat]] |
[[Category: Jingami, H]] | [[Category: Jingami, H]] | ||
[[Category: Morikawa, K]] | [[Category: Morikawa, K]] | ||
Revision as of 10:45, 10 September 2015
Crystal structure of the extracellular region of the group II metabotropic glutamate receptor complexed with L-glutamate
| |||||||||||
