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1uwv

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(New page: 200px<br /> <applet load="1uwv" size="450" color="white" frame="true" align="right" spinBox="true" caption="1uwv, resolution 1.95&Aring;" /> '''CRYSTAL STRUCTURE O...)
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Revision as of 15:01, 29 October 2007

Image:1uwv.gif

1uwv, resolution 1.95Å

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CRYSTAL STRUCTURE OF RUMA, THE IRON-SULFUR CLUSTER CONTAINING E. COLI 23S RIBOSOMAL RNA 5-METHYLURIDINE METHYLTRANSFERASE

Overview

RumA catalyzes transfer of a methyl group from S-adenosylmethionine (SAM), specifically to uridine 1939 of 23S ribosomal RNA in Escherichia coli to, yield 5-methyluridine. We determined the crystal structure of RumA at 1.95, A resolution. The protein is organized into three structural domains: The, N-terminal domain contains sequence homology to the conserved TRAM motif, and displays a five-stranded beta barrel architecture characteristic of an, oligosaccharide/oligonucleotide binding fold. The central domain contains, a [Fe(4)S(4)] cluster coordinated by four conserved cysteine residues. The, C-terminal domain displays the typical SAM-dependent methyltransferase, fold. The catalytic nucleophile Cys389 lies in a motif different from that, in DNA 5-methylcytosine methyltransferases. The ... [(full description)]

About this Structure

1UWV is a [Single protein] structure of sequence from [Escherichia coli] with NI, PO4, CL and SF4 as [ligands]. Full crystallographic information is available from [OCA].

Reference

Crystal structure of RumA, an iron-sulfur cluster containing E. coli ribosomal RNA 5-methyluridine methyltransferase., Lee TT, Agarwalla S, Stroud RM, Structure. 2004 Mar;12(3):397-407. PMID:15016356

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