2biw

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|PDB= 2biw |SIZE=350|CAPTION= <scene name='initialview01'>2biw</scene>, resolution 2.39&Aring;
|PDB= 2biw |SIZE=350|CAPTION= <scene name='initialview01'>2biw</scene>, resolution 2.39&Aring;
|SITE= <scene name='pdbsite=AC1:Fe+Binding+Site+For+Chain+D'>AC1</scene>
|SITE= <scene name='pdbsite=AC1:Fe+Binding+Site+For+Chain+D'>AC1</scene>
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|LIGAND= <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene> and <scene name='pdbligand=3ON:(3R)-3-HYDROXY-8'-APOCAROTENOL'>3ON</scene>
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|LIGAND= <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene> and <scene name='pdbligand=3ON:(3R)-3-HYDROXY-8&#39;-APOCAROTENOL'>3ON</scene>
|ACTIVITY=
|ACTIVITY=
|GENE=
|GENE=
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[[Category: retinal formation]]
[[Category: retinal formation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:02:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 14:45:23 2008''

Revision as of 12:45, 23 March 2008

Image:2biw.gif


PDB ID 2biw

Drag the structure with the mouse to rotate
, resolution 2.39Å
Sites:
Ligands: and
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF APOCAROTENOID CLEAVAGE OXYGENASE FROM SYNECHOCYSTIS, NATIVE ENZYME


Overview

Enzymes that produce retinal and related apocarotenoids constitute a sequence- and thus structure-related family, a member of which was analyzed by x-ray diffraction. This member is an oxygenase and contains an Fe2+-4-His arrangement at the axis of a seven-bladed beta-propeller chain fold covered by a dome formed by six large loops. The Fe2+ is accessible through a long nonpolar tunnel that holds a carotenoid derivative in one of the crystals. On binding, three consecutive double bonds of this carotenoid changed from a straight all-trans to a cranked cis-trans-cis conformation. The remaining trans bond is located at the dioxygen-ligated Fe2+ and cleaved by oxygen.

About this Structure

2BIW is a Single protein structure of sequence from Synechocystis sp.. The following page contains interesting information on the relation of 2BIW with [Carotenoid Oxygenase]. Full crystallographic information is available from OCA.

Reference

The structure of a retinal-forming carotenoid oxygenase., Kloer DP, Ruch S, Al-Babili S, Beyer P, Schulz GE, Science. 2005 Apr 8;308(5719):267-9. PMID:15821095

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