1y7h

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<StructureSection load='1y7h' size='340' side='right' caption='[[1y7h]], [[Resolution|resolution]] 2.52&Aring;' scene=''>
<StructureSection load='1y7h' size='340' side='right' caption='[[1y7h]], [[Resolution|resolution]] 2.52&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1y7h]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Nicotiana_tabacum Nicotiana tabacum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y7H FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1y7h]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/American_tobacco American tobacco]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y7H FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xkl|1xkl]], [[1y7i|1y7i]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xkl|1xkl]], [[1y7i|1y7i]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y7h RCSB], [http://www.ebi.ac.uk/pdbsum/1y7h PDBsum], [http://www.topsan.org/Proteins/NESGC/1y7h TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7h OCA], [http://pdbe.org/1y7h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y7h RCSB], [http://www.ebi.ac.uk/pdbsum/1y7h PDBsum], [http://www.topsan.org/Proteins/NESGC/1y7h TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/Q6RYA0_TOBAC Q6RYA0_TOBAC]] Required to convert methyl salicylate (MeSA) to salicylic acid (SA) as part of the signal transduction pathways that activate systemic acquired resistance in systemic tissue. MeSA is believed to be an inactive form that needs to be demethylated to exert a biological effect. Also able to catalyze the conversion of acibenzolar-S-methyl into acibenzolar to induce systemic acquired resistance.<ref>PMID:14673096</ref> <ref>PMID:17916738</ref> <ref>PMID:19131332</ref> <ref>PMID:20797615</ref> <ref>PMID:20621100</ref> <ref>PMID:15668381</ref>
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[[http://www.uniprot.org/uniprot/SABP2_TOBAC SABP2_TOBAC]] Required to convert methyl salicylate (MeSA) to salicylic acid (SA) as part of the signal transduction pathways that activate systemic acquired resistance in systemic tissue. MeSA is believed to be an inactive form that needs to be demethylated to exert a biological effect. Also able to catalyze the conversion of acibenzolar-S-methyl into acibenzolar to induce systemic acquired resistance.<ref>PMID:14673096</ref> <ref>PMID:15668381</ref> <ref>PMID:17916738</ref> <ref>PMID:19131332</ref> <ref>PMID:20621100</ref> <ref>PMID:20797615</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 1y7h" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Nicotiana tabacum]]
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[[Category: American tobacco]]
[[Category: Acton, T B]]
[[Category: Acton, T B]]
[[Category: Chen, Y]]
[[Category: Chen, Y]]

Revision as of 15:19, 10 September 2015

Structural and biochemical studies identify tobacco SABP2 as a methylsalicylate esterase and further implicate it in plant innate immunity, Northeast Structural Genomics Target AR2241

1y7h, resolution 2.52Å

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