2gqq

From Proteopedia

(Difference between revisions)

Revision as of 15:40, 10 September 2015

Crystal Structure of E. coli Leucine-responsive regulatory protein (Lrp)

Structural highlights

2gqq is a 4 chain structure with sequence from "bacillus_coli"_migula_1895 "bacillus coli" migula 1895. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	lrp, alsB, ihb, livR, oppI ("Bacillus coli" Migula 1895)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum

Function

[LRP_ECOLI] Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The structure of Escherichia coli leucine-responsive regulatory protein (Lrp) co-crystallized with a short duplex oligodeoxynucleotide reveals a novel quaternary assembly in which the protein octamer forms an open, linear array of four dimers. In contrast, structures of the Lrp homologs LrpA, LrpC and AsnC crystallized in the absence of DNA show that these proteins instead form highly symmetrical octamers in which the four dimers form a closed ring. Although the DNA is disordered within the Lrp crystal, comparative analyses suggest that the observed differences in quaternary state may arise from DNA interactions during crystallization. Interconversion of these conformations, possibly in response to DNA or leucine binding, provides an underlying mechanism to alter the relative spatial orientation of the DNA-binding domains. Breaking of the closed octamer symmetry may be a common essential step in the formation of active DNA complexes by all members of the Lrp/AsnC family of transcriptional regulatory proteins.

Structure of the Escherichia coli leucine-responsive regulatory protein Lrp reveals a novel octameric assembly.,de los Rios S, Perona JJ J Mol Biol. 2007 Mar 9;366(5):1589-602. Epub 2006 Dec 19. PMID:17223133^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ de los Rios S, Perona JJ. Structure of the Escherichia coli leucine-responsive regulatory protein Lrp reveals a novel octameric assembly. J Mol Biol. 2007 Mar 9;366(5):1589-602. Epub 2006 Dec 19. PMID:17223133 doi:10.1016/j.jmb.2006.12.032

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2gqq"

Categories: Bacillus coli migula 1895 | Perona, J J | Rios, S de los | Helix-turn-helix | Transcription

@@ Line 2: / Line 2: @@
 <StructureSection load='2gqq' size='340' side='right' caption='[[2gqq]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2gqq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GQQ FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2gqq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GQQ FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lrp, alsB, ihb, livR, oppI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lrp, alsB, ihb, livR, oppI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gqq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gqq RCSB], [http://www.ebi.ac.uk/pdbsum/2gqq PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gqq OCA], [http://pdbe.org/2gqq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2gqq RCSB], [http://www.ebi.ac.uk/pdbsum/2gqq PDBsum]</span></td></tr>
 </table>
 == Function ==
@@ Line 26: / Line 26: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 2gqq" style="background-color:#fffaf0;"></div>
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Escherichia coli]]
+[[Category: Bacillus coli migula 1895]]
 [[Category: Perona, J J]]
 [[Category: Rios, S de los]]
 [[Category: Helix-turn-helix]]
 [[Category: Transcription]]

2gqq

From Proteopedia

Revision as of 15:40, 10 September 2015

Crystal Structure of E. coli Leucine-responsive regulatory protein (Lrp)

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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