2bai

From Proteopedia

(Difference between revisions)

Revision as of 16:40, 10 September 2015

The Zinc finger domain of Mengovirus Leader polypeptide

Structural highlights

2bai is a 1 chain structure with sequence from Enmgo. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, TOPSAN

Function

[POLG_ENMG3] Capsid proteins VP1, VP2, VP3 and VP4 form a closed capsid enclosing the viral positive strand RNA genome. VP4 lies on the inner surface of the protein shell formed by VP1, VP2 and VP3. All the three latter proteins contain a beta-sheet structure called beta-barrel jelly roll. Together they form an icosahedral capsid (T=3) composed of 60 copies of each VP1, VP2, and VP3, with a diameter of approximately 300 Angstroms. VP1 is situated at the 12 fivefold axes, whereas VP2 and VP3 are located at the quasi-sixfold axes (By similarity). Protein VP0: VP0 precursor is a component of immature procapsids (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The Leader protein is a defining feature of picornaviruses from the Cardiovirus genus. This protein was recently shown to inhibit cellular nucleocytoplasmic transport through an activity mapped to its zinc-binding region. Here we report the three-dimensional solution structure determined by nuclear magnetic resonance (NMR) spectroscopy of this domain (residues 5-28) from mengovirus. The domain forms a CHCC zinc-finger with a fold comprising a beta-hairpin followed by a short alpha-helix that can adopt two different conformations. This structure is divergent from those of other eukaryotic zinc-fingers and instead resembles motifs found in a group of DNA-binding proteins from Archaea.

NMR structure of the mengovirus Leader protein zinc-finger domain.,Cornilescu CC, Porter FW, Zhao KQ, Palmenberg AC, Markley JL FEBS Lett. 2008 Mar 19;582(6):896-900. Epub 2008 Feb 20. PMID:18291103^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Cornilescu CC, Porter FW, Zhao KQ, Palmenberg AC, Markley JL. NMR structure of the mengovirus Leader protein zinc-finger domain. FEBS Lett. 2008 Mar 19;582(6):896-900. Epub 2008 Feb 20. PMID:18291103 doi:10.1016/j.febslet.2008.02.023

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2bai"

@@ Line 2: / Line 2: @@
 <StructureSection load='2bai' size='340' side='right' caption='[[2bai]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2bai]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mengo_virus Mengo virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BAI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BAI FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2bai]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enmgo Enmgo]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BAI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BAI FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bai OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bai RCSB], [http://www.ebi.ac.uk/pdbsum/2bai PDBsum], [http://www.topsan.org/Proteins/CESG/2bai TOPSAN]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bai OCA], [http://pdbe.org/2bai PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bai RCSB], [http://www.ebi.ac.uk/pdbsum/2bai PDBsum], [http://www.topsan.org/Proteins/CESG/2bai TOPSAN]</span></td></tr>
 </table>
 == Function ==
@@ Line 26: / Line 26: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 2bai" style="background-color:#fffaf0;"></div>
 ==See Also==
@@ Line 33: / Line 34: @@
 __TOC__
 </StructureSection>
-[[Category: Mengo virus]]
+[[Category: Enmgo]]
 [[Category: Structural genomic]]
 [[Category: Cornilescu, C C]]

2bai

From Proteopedia

Revision as of 16:40, 10 September 2015

The Zinc finger domain of Mengovirus Leader polypeptide

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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