2hck

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|PDB= 2hck |SIZE=350|CAPTION= <scene name='initialview01'>2hck</scene>, resolution 3.0&Aring;
|PDB= 2hck |SIZE=350|CAPTION= <scene name='initialview01'>2hck</scene>, resolution 3.0&Aring;
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=QUE:3,5,7,3',4'-PENTAHYDROXYFLAVONE'>QUE</scene>
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=QUE:3,5,7,3&#39;,4&#39;-PENTAHYDROXYFLAVONE'>QUE</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2]
|ACTIVITY= [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2]
|GENE= HUMAN HCK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
|GENE= HUMAN HCK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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[[Category: transferase]]
[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:15:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 15:14:48 2008''

Revision as of 13:14, 23 March 2008

Image:2hck.gif


PDB ID 2hck

Drag the structure with the mouse to rotate
, resolution 3.0Å
Ligands: and
Gene: HUMAN HCK (Homo sapiens)
Activity: Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2
Coordinates: save as pdb, mmCIF, xml



SRC FAMILY KINASE HCK-QUERCETIN COMPLEX


Overview

The crystal structure of the haematopoietic cell kinase Hck has been determined at 2.6/2.9 A resolution. Inhibition of enzymatic activity is a consequence of intramolecular interactions of the enzyme's Src-homology domains SH2 and SH3, with concomitant displacement of elements of the catalytic domain. The conformation of the active site has similarities with that of inactive cyclin-dependent protein kinases.

About this Structure

2HCK is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 2HCK with [Src Tyrosine Kinase]. Full crystallographic information is available from OCA.

Reference

Crystal structure of the Src family tyrosine kinase Hck., Sicheri F, Moarefi I, Kuriyan J, Nature. 1997 Feb 13;385(6617):602-9. PMID:9024658

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