2p71

From Proteopedia

(Difference between revisions)

Revision as of 17:27, 10 September 2015

Bombyx mori pheromone binding protein bound to iodohexadecane

Structural highlights

2p71 is a 1 chain structure with sequence from Bommo. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Related:	1dqe, 2fjy, 2p70
Gene:	pheromone binding protein (BOMMO)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum

Function

[PBP_BOMMO] This major soluble protein in olfactory sensilla of male moths serves to solubilize the extremely hydrophobic pheromone molecules such as bombykol and to transport pheromone through the aqueous lymph to receptors located on olfactory cilia.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Insect pheromone-binding proteins (PBPs) transport sex pheromones through the aqueous layer surrounding G protein-coupled receptors that initiate signaling events leading to mating. This PBP-receptor system strongly discriminates between ligands with subtle structural differences, but it has proved difficult to distinguish the degree of discrimination of the PBP from that of the G protein-coupled receptor. The three-dimensional structures of the PBP of Bombyx mori, the silkworm moth, both with and without its cognate ligand bombykol ([E,Z]-10,12-hexadecadienol), have been determined by X-ray crystallography and NMR. In this paper, the structures of the same binding protein with bound iodohexadecane and bell pepper odorant were determined at 1.9 and 2.0 A, respectively. These structures illustrate the remarkable plasticity in the ligand binding site of the PBP, but suggest the protein might still act as a filter during pheromone signal processing.

Bombyx mori pheromone-binding protein binding nonpheromone ligands: implications for pheromone recognition.,Lautenschlager C, Leal WS, Clardy J Structure. 2007 Sep;15(9):1148-54. PMID:17850754^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Lautenschlager C, Leal WS, Clardy J. Bombyx mori pheromone-binding protein binding nonpheromone ligands: implications for pheromone recognition. Structure. 2007 Sep;15(9):1148-54. PMID:17850754 doi:10.1016/j.str.2007.07.013

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2p71"

@@ Line 2: / Line 2: @@
 <StructureSection load='2p71' size='340' side='right' caption='[[2p71]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2p71]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bombyx_mori Bombyx mori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P71 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P71 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2p71]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bommo Bommo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P71 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P71 FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IHD:1-IODOHEXADECANE'>IHD</scene></td></tr>
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1dqe|1dqe]], [[2fjy|2fjy]], [[2p70|2p70]]</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pheromone binding protein ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7091 Bombyx mori])</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pheromone binding protein ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7091 BOMMO])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p71 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p71 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2p71 RCSB], [http://www.ebi.ac.uk/pdbsum/2p71 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p71 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p71 OCA], [http://pdbe.org/2p71 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2p71 RCSB], [http://www.ebi.ac.uk/pdbsum/2p71 PDBsum]</span></td></tr>
 </table>
 == Function ==
@@ Line 28: / Line 28: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 2p71" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Pheromone binding protein|Pheromone binding protein]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Bombyx mori]]
+[[Category: Bommo]]
 [[Category: Clardy, J]]
 [[Category: Lautenschlager, C L]]

2p71

From Proteopedia

Revision as of 17:27, 10 September 2015

Bombyx mori pheromone binding protein bound to iodohexadecane

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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