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2c6j

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Revision as of 21:47, 10 September 2015

STRUCTURE OF P. KNOWLESI DBL DOMAIN CAPABLE OF BINDING HUMAN DUFFY ANTIGEN

Structural highlights

2c6j is a 1 chain structure with sequence from Plakn. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Molecular processes that govern pathogenic features of erythrocyte invasion and cytoadherence in malaria are reliant on Plasmodium-specific Duffy-binding-like domains (DBLs). These cysteine-rich modules recognize diverse host cell-surface receptors during pathogenesis. DBLs of parasite erythrocyte-binding proteins mediate invasion, and those from the antigenically variant P. falciparum erythrocyte membrane protein 1 (PfEMP1) have been implicated in cytoadherence. The simian and human malarial parasites, P. knowlesi and P. vivax, invade human erythrocytes exclusively through the host DARC receptor (Duffy antigen receptor for chemokines). Here we present the crystal structure of the P. knowlesi DBL domain (Pkalpha-DBL), which binds to DARC during invasion of human erythrocytes. Pkalpha-DBL retains the overall fold observed in DBLs from P. falciparum erythrocyte-binding antigen (EBA)-175 (ref. 4). Mapping the residues that have previously been implicated in binding highlights a fairly flat but exposed site for DARC recognition in subdomain 2 of Pkalpha-DBL; this is in sharp contrast to receptor recognition by EBA-175 (ref. 4). In Pkalpha-DBL, the residues that contact DARC and the clusters of residues under immune pressure map to opposite surfaces of the DBL, and suggest a possible mechanism for immune evasion by P. vivax. Our comparative structural analysis of Pkalpha-DBL and P. falciparum EBA-175 provides a framework for the understanding of malaria parasite DBLs, and may affect the development of new prophylactic and therapeutic strategies.

Structural basis for Duffy recognition by the malaria parasite Duffy-binding-like domain.,Singh SK, Hora R, Belrhali H, Chitnis CE, Sharma A Nature. 2006 Feb 9;439(7077):741-4. Epub 2005 Dec 21. PMID:16372020^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Singh SK, Hora R, Belrhali H, Chitnis CE, Sharma A. Structural basis for Duffy recognition by the malaria parasite Duffy-binding-like domain. Nature. 2006 Feb 9;439(7077):741-4. Epub 2005 Dec 21. PMID:16372020 doi:10.1038/nature04443

1 Structural highlights
2 Evolutionary Conservation
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2c6j"

@@ Line 2: / Line 2: @@
 <StructureSection load='2c6j' size='340' side='right' caption='[[2c6j]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2c6j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_knowlesi Plasmodium knowlesi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C6J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C6J FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2c6j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plakn Plakn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C6J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C6J FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c6j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c6j RCSB], [http://www.ebi.ac.uk/pdbsum/2c6j PDBsum]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c6j OCA], [http://pdbe.org/2c6j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c6j RCSB], [http://www.ebi.ac.uk/pdbsum/2c6j PDBsum]</span></td></tr>
 </table>
 == Evolutionary Conservation ==
@@ Line 23: / Line 23: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 2c6j" style="background-color:#fffaf0;"></div>
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Plasmodium knowlesi]]
+[[Category: Plakn]]
 [[Category: Belrhali, H]]
 [[Category: Chitnis, C]]

2c6j

From Proteopedia

Revision as of 21:47, 10 September 2015

STRUCTURE OF P. KNOWLESI DBL DOMAIN CAPABLE OF BINDING HUMAN DUFFY ANTIGEN

Structural highlights

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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