2vb6

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|PDB= 2vb6 |SIZE=350|CAPTION= <scene name='initialview01'>2vb6</scene>, resolution 2.30&Aring;
|PDB= 2vb6 |SIZE=350|CAPTION= <scene name='initialview01'>2vb6</scene>, resolution 2.30&Aring;
|SITE= <scene name='pdbsite=AC1:Adp+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Bef+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:Mg+Binding+Site+For+Chain+A'>AC3</scene>, <scene name='pdbsite=AC4:Ca+Binding+Site+For+Chain+B'>AC4</scene>, <scene name='pdbsite=AC5:Ca+Binding+Site+For+Chain+B'>AC5</scene>, <scene name='pdbsite=AC6:Ca+Binding+Site+For+Chain+B'>AC6</scene> and <scene name='pdbsite=AC7:Ca+Binding+Site+For+Chain+B'>AC7</scene>
|SITE= <scene name='pdbsite=AC1:Adp+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Bef+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:Mg+Binding+Site+For+Chain+A'>AC3</scene>, <scene name='pdbsite=AC4:Ca+Binding+Site+For+Chain+B'>AC4</scene>, <scene name='pdbsite=AC5:Ca+Binding+Site+For+Chain+B'>AC5</scene>, <scene name='pdbsite=AC6:Ca+Binding+Site+For+Chain+B'>AC6</scene> and <scene name='pdbsite=AC7:Ca+Binding+Site+For+Chain+B'>AC7</scene>
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ADP:ADENOSINE-5'-DIPHOSPHATE'>ADP</scene> and <scene name='pdbligand=BEF:BERYLLIUM TRIFLUORIDE ION'>BEF</scene>
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene> and <scene name='pdbligand=BEF:BERYLLIUM TRIFLUORIDE ION'>BEF</scene>
|ACTIVITY=
|ACTIVITY=
|GENE=
|GENE=
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[[Category: post-rigor state]]
[[Category: post-rigor state]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:45:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 15:53:31 2008''

Revision as of 13:53, 23 March 2008

Image:2vb6.jpg


PDB ID 2vb6

Drag the structure with the mouse to rotate
, resolution 2.30Å
Sites: , , , , , and
Ligands: , , and
Coordinates: save as pdb, mmCIF, xml



MYOSIN VI (MD-INSERT2-CAM, DELTA INSERT1) POST-RIGOR STATE (CRYSTAL FORM 2)


Overview

Myosin VI has an unexpectedly large swing of its lever arm (powerstroke) that optimizes its unique reverse direction movement. The basis for this is an unprecedented rearrangement of the subdomain to which the lever arm is attached, referred to as the converter. It is unclear at what point(s) in the myosin VI ATPase cycle rearrangements in the converter occur, and how this would effect lever arm position. We solved the structure of myosin VI with an ATP analogue (ADP.BeF3) bound in its nucleotide-binding pocket. The structure reveals that no rearrangement in the converter occur upon ATP binding. Based on previously solved myosin structures, our structure suggests that no reversal of the powerstroke occurs during detachment of myosin VI from actin. The structure also reveals novel features of the myosin VI motor that may be important in maintaining the converter conformation during detachment from actin, and other features that may promote rapid rearrangements in the structure following actin detachment that enable hydrolysis of ATP.

About this Structure

2VB6 is a Protein complex structure of sequences from Gallus gallus and Sus scrofa. Full crystallographic information is available from OCA.

Reference

The post-rigor structure of myosin VI and implications for the recovery stroke., Menetrey J, Llinas P, Cicolari J, Squires G, Liu X, Li A, Sweeney HL, Houdusse A, EMBO J. 2008 Jan 9;27(1):244-52. Epub 2007 Nov 29. PMID:18046460

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