1dus

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|PDB= 1dus |SIZE=350|CAPTION= <scene name='initialview01'>1dus</scene>, resolution 1.80&Aring;
|PDB= 1dus |SIZE=350|CAPTION= <scene name='initialview01'>1dus</scene>, resolution 1.80&Aring;
|SITE=
|SITE=
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|LIGAND=
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
|ACTIVITY=
|ACTIVITY=
|GENE=
|GENE=
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam05175 MTS]</span>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dus OCA], [http://www.ebi.ac.uk/pdbsum/1dus PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=1dus RCSB]</span>
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[[Category: structural genomic]]
[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:44:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 05:51:28 2008''

Revision as of 03:51, 26 March 2008

Image:1dus.gif


PDB ID 1dus

Drag the structure with the mouse to rotate
, resolution 1.80Å
Ligands:
Domains: MTS
Resources: FirstGlance, OCA, PDBsum, JenaLib, RCSB
Coordinates: save as pdb, mmCIF, xml



MJ0882-A hypothetical protein from M. jannaschii


Overview

We have determined the three-dimensional (3-D) structure of protein MJ0882, which derives from a hypothetical open reading frame in the genome of the hyperthermophile Methanococcus jannaschii. The 3-D fold of MJ0882 at 1.8 A highly resembles that of a methyltransferase, despite limited sequence similarity to any confirmed methyltransferase. The structure has an S-adenosylmethionine (AdoMet) binding pocket surrounded by motifs with similarities to those commonly found among AdoMet binding proteins. Preliminary biochemical experiments show that MJ0882 specifically binds to AdoMet, which is the essential co-factor for methyltransferases.

About this Structure

1DUS is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.

Reference

Structure-based experimental confirmation of biochemical function to a methyltransferase, MJ0882, from hyperthermophile Methanococcus jannaschii., Huang L, Hung L, Odell M, Yokota H, Kim R, Kim SH, J Struct Funct Genomics. 2002;2(3):121-7. PMID:12836702

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