1tly

From Proteopedia

(Difference between revisions)

Revision as of 11:37, 11 September 2015

Tsx structure

Structural highlights

1tly is a 2 chain structure with sequence from "bacillus_coli"_migula_1895 "bacillus coli" migula 1895. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	1tlw, 1tlz
Gene:	TSX, NUPA, B0411, Z0512, ECS0464, SF0348, S0356 ("Bacillus coli" Migula 1895)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum

Function

[TSX_ECOLI] Constitutes the receptor for colicin K and phage T6, and functions as substrate-specific channel for nucleosides and deoxynucleosides.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Tsx is a nucleoside-specific outer membrane (OM) transporter of Gram-negative bacteria. We present crystal structures of Escherichia coli Tsx in the absence and presence of nucleosides. These structures provide a mechanism for nucleoside transport across the bacterial OM. Tsx forms a monomeric, 12-stranded beta-barrel with a long and narrow channel spanning the outer membrane. The channel, which is shaped like a keyhole, contains several distinct nucleoside-binding sites, two of which are well defined. The base moiety of the nucleoside is located in the narrow part of the keyhole, while the sugar occupies the wider opening. Pairs of aromatic residues and flanking ionizable residues are involved in nucleoside binding. Nucleoside transport presumably occurs by diffusion from one binding site to the next.

Crystal structure of the bacterial nucleoside transporter Tsx.,Ye J, van den Berg B EMBO J. 2004 Aug 18;23(16):3187-95. Epub 2004 Jul 22. PMID:15272310^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Ye J, van den Berg B. Crystal structure of the bacterial nucleoside transporter Tsx. EMBO J. 2004 Aug 18;23(16):3187-95. Epub 2004 Jul 22. PMID:15272310 doi:10.1038/sj.emboj.7600330

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1tly"

@@ Line 5: / Line 5: @@
 </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1tlw|1tlw]], [[1tlz|1tlz]]</td></tr>
 <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TSX, NUPA, B0411, Z0512, ECS0464, SF0348, S0356 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tly FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tly OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tly RCSB], [http://www.ebi.ac.uk/pdbsum/1tly PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tly FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tly OCA], [http://pdbe.org/1tly PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tly RCSB], [http://www.ebi.ac.uk/pdbsum/1tly PDBsum]</span></td></tr>
 </table>
 == Function ==
@@ Line 27: / Line 27: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 1tly" style="background-color:#fffaf0;"></div>
 == References ==
 <references/>

1tly

From Proteopedia

Revision as of 11:37, 11 September 2015

Tsx structure

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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