1s12

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|PDB= 1s12 |SIZE=350|CAPTION= <scene name='initialview01'>1s12</scene>, resolution 2.00&Aring;
|PDB= 1s12 |SIZE=350|CAPTION= <scene name='initialview01'>1s12</scene>, resolution 2.00&Aring;
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=ACT:ACETATE ION'>ACT</scene>
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|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>
|ACTIVITY=
|ACTIVITY=
|GENE=
|GENE=
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam04327 DUF464]</span>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s12 OCA], [http://www.ebi.ac.uk/pdbsum/1s12 PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=1s12 RCSB]</span>
}}
}}
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[[Category: Shin, D H.]]
[[Category: Shin, D H.]]
[[Category: Yokota, H.]]
[[Category: Yokota, H.]]
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[[Category: ACT]]
 
[[Category: berkeley structural genomics center]]
[[Category: berkeley structural genomics center]]
[[Category: bsgc]]
[[Category: bsgc]]
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[[Category: structural genomic]]
[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:59:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 06:03:56 2008''

Revision as of 04:03, 26 March 2008

Image:1s12.gif


PDB ID 1s12

Drag the structure with the mouse to rotate
, resolution 2.00Å
Ligands:
Domains: DUF464
Resources: FirstGlance, OCA, PDBsum, JenaLib, RCSB
Coordinates: save as pdb, mmCIF, xml



Crystal structure of TM1457


Overview

The crystal structure of a hypothetical protein, TM1457, from Thermotoga maritima has been determined at 2.0A resolution. TM1457 belongs to the DUF464 family (57 members) for which there is no known function. The structure shows that it is composed of two helices in contact with one side of a five-stranded beta-sheet. Two identical monomers form a pseudo-dimer in the asymmetric unit. There is a large cleft between the first alpha-helix and the second beta-strand. This cleft may be functionally important, since the two highly conserved motifs, GHA and VCAXV(S/T), are located around the cleft. A structural comparison of TM1457 with known protein structures shows the best hit with another hypothetical protein, Ybl001C from Saccharomyces cerevisiae, though they share low structural similarity. Therefore, TM1457 still retains a unique topology and reveals a novel fold.

About this Structure

1S12 is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

Crystal structure of TM1457 from Thermotoga maritima., Shin DH, Lou Y, Jancarik J, Yokota H, Kim R, Kim SH, J Struct Biol. 2005 Nov;152(2):113-7. Epub 2005 Oct 3. PMID:16242963

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