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1dgn

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<StructureSection load='1dgn' size='340' side='right' caption='[[1dgn]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1dgn' size='340' side='right' caption='[[1dgn]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1dgn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DGN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DGN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1dgn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DGN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DGN FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dgn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dgn RCSB], [http://www.ebi.ac.uk/pdbsum/1dgn PDBsum]</span></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dgn OCA], [http://pdbe.org/1dgn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dgn RCSB], [http://www.ebi.ac.uk/pdbsum/1dgn PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ICBR_HUMAN ICBR_HUMAN]] Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B.<ref>PMID:11051551</ref>
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[[http://www.uniprot.org/uniprot/CAR18_HUMAN CAR18_HUMAN]] Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B.<ref>PMID:11051551</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 1dgn" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Human]]
[[Category: Dixit, V M]]
[[Category: Dixit, V M]]
[[Category: Fairbrother, W J]]
[[Category: Fairbrother, W J]]

Revision as of 13:44, 11 September 2015

SOLUTION STRUCTURE OF ICEBERG, AN INHIBITOR OF INTERLEUKIN-1BETA GENERATION

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