1m2s
From Proteopedia
(Difference between revisions)
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<table><tr><td colspan='2'>[[1m2s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M2S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M2S FirstGlance]. <br> | <table><tr><td colspan='2'>[[1m2s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M2S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M2S FirstGlance]. <br> | ||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1big|1big]], [[2bmt|2bmt]], [[2crd|2crd]], [[1lir|1lir]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1big|1big]], [[2bmt|2bmt]], [[2crd|2crd]], [[1lir|1lir]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m2s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1m2s RCSB], [http://www.ebi.ac.uk/pdbsum/1m2s PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m2s OCA], [http://pdbe.org/1m2s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1m2s RCSB], [http://www.ebi.ac.uk/pdbsum/1m2s PDBsum]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KA162_MESMA KA162_MESMA]] Alpha-KTx 16.2: inhibits large conductance calcium-activated potassium channels (KCa1.1/Slo-beta4 KCNMA1/KCNMB4). It appears to block channel activity by a simple bimolecular inhibition process. Shows a fast association rate and a slow dissociation rate of binding on rat brain synaptosome (PubMed:18199674). Significantly inhibits voltage-dependent sodium current and voltage-dependent delayed rectifier potassium currents (PubMed:14632928).<ref>PMID:14632928</ref> <ref>PMID:18199674</ref> Martentoxin-1: significantly inhibits voltage-dependent sodium current (Nav) and voltage-dependent delayed rectifier potassium current.<ref>PMID:14632928</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 1m2s" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
Revision as of 14:17, 11 September 2015
Solution Structure of A New Potassium Channels Blocker from the Venom of Chinese Scorpion Buthus martensi Karsch
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Categories: Mesobuthus martensii | Hu, G | Li, M | Wang, Y | Wu, G | Wu, H | Zhang, N | Alpha/beta scaffold | Toxin
