1y0h

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|PDB= 1y0h |SIZE=350|CAPTION= <scene name='initialview01'>1y0h</scene>, resolution 1.600&Aring;
|PDB= 1y0h |SIZE=350|CAPTION= <scene name='initialview01'>1y0h</scene>, resolution 1.600&Aring;
|SITE=
|SITE=
-
|LIGAND= <scene name='pdbligand=ACT:ACETATE ION'>ACT</scene>
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|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>
|ACTIVITY=
|ACTIVITY=
|GENE= Rv0793 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])
|GENE= Rv0793 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])
 +
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1359 COG1359]</span>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y0h OCA], [http://www.ebi.ac.uk/pdbsum/1y0h PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=1y0h RCSB]</span>
}}
}}
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[[Category: TBSGC, TB Structural Genomics Consortium.]]
[[Category: TBSGC, TB Structural Genomics Consortium.]]
[[Category: Wang, M.]]
[[Category: Wang, M.]]
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[[Category: ACT]]
 
[[Category: alpha+beta sandwich with antiparallel beta-sheet]]
[[Category: alpha+beta sandwich with antiparallel beta-sheet]]
[[Category: ferredoxin-like fold]]
[[Category: ferredoxin-like fold]]
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[[Category: tbsgc]]
[[Category: tbsgc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:16:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 06:13:22 2008''

Revision as of 04:13, 26 March 2008

Image:1y0h.gif


PDB ID 1y0h

Drag the structure with the mouse to rotate
, resolution 1.600Å
Ligands:
Gene: Rv0793 (Mycobacterium tuberculosis)
Domains: COG1359
Resources: FirstGlance, OCA, PDBsum, JenaLib, RCSB
Coordinates: save as pdb, mmCIF, xml



Structure of Rv0793 from Mycobacterium tuberculosis


Overview

Mycobacterium tuberculosis infects millions worldwide. The Structural Genomics Consortium for M. tuberculosis has targeted all genes from this bacterium in hopes of discovering and developing new therapeutic agents. Open reading frame Rv0793 from M. tuberculosis was annotated with an unknown function. The 3-dimensional structure of Rv0793 has been solved to 1.6 A resolution. Its structure is very similar to that of Streptomyces coelicolor ActVA-Orf6, a monooxygenase that participates in tailoring of polyketide antibiotics in the absence of a cofactor. It is also similar to the recently solved structure of YgiN, a quinol monooxygenase from Escherichia coli. In addition, the structure of Rv0793 is similar to several structures of other proteins with unknown function. These latter structures have been determined recently as a result of structural genomic projects for various bacterial species. In M. tuberculosis, Rv0793 and its homologs may represent a class of monooygenases acting as reactive oxygen species scavengers that are essential for evading host defenses. Since the most prevalent mode of attack by the host defense on M. tuberculosis is by reactive oxygen species and reactive nitrogen species, Rv0793 may provide a novel target to combat infection by M. tuberculosis.

About this Structure

1Y0H is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

The crystal structure of Rv0793, a hypothetical monooxygenase from M. tuberculosis., Lemieux MJ, Ference C, Cherney MM, Wang M, Garen C, James MN, J Struct Funct Genomics. 2005 Dec;6(4):245-57. Epub 2006 Feb 22. PMID:16496224

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