2h3p
From Proteopedia
(Difference between revisions)
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<StructureSection load='2h3p' size='340' side='right' caption='[[2h3p]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='2h3p' size='340' side='right' caption='[[2h3p]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2h3p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2h3p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H3P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2H3P FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=152:CARNITINE'>152</scene>, <scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=152:CARNITINE'>152</scene>, <scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ndb|1ndb]], [[1ndf|1ndf]], [[1ndi|1ndi]], [[1t7q|1t7q]], [[1t7n|1t7n]], [[1t7o|1t7o]], [[2h3u|2h3u]], [[2h3w|2h3w]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ndb|1ndb]], [[1ndf|1ndf]], [[1ndi|1ndi]], [[1t7q|1t7q]], [[1t7n|1t7n]], [[1t7o|1t7o]], [[2h3u|2h3u]], [[2h3w|2h3w]]</td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Crat ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Crat ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h3p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2h3p RCSB], [http://www.ebi.ac.uk/pdbsum/2h3p PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h3p OCA], [http://pdbe.org/2h3p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2h3p RCSB], [http://www.ebi.ac.uk/pdbsum/2h3p PDBsum]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CACP_MOUSE CACP_MOUSE]] Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2h3p" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Lk3 transgenic mice]] |
[[Category: Hsiao, Y S]] | [[Category: Hsiao, Y S]] | ||
[[Category: Jogl, G]] | [[Category: Jogl, G]] | ||
Revision as of 17:25, 11 September 2015
Crystal structure of murine carnitine acetyltransferase in complex with carnitine and acetyl-CoA
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