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2m2e

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Revision as of 22:12, 11 September 2015

Solution NMR structure of the SANT domain of human DNAJC2, Northeast structural genomics consortium target HR8254a

Structural highlights

2m2e is a 1 chain structure with sequence from Human. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	DNAJC2, MPHOSPH11, MPP11, ZRF1 (HUMAN)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum

Function

[DNJC2_HUMAN] Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'.^[1] ^[2] ^[3]

References

↑ Otto H, Conz C, Maier P, Wolfle T, Suzuki CK, Jeno P, Rucknagel P, Stahl J, Rospert S. The chaperones MPP11 and Hsp70L1 form the mammalian ribosome-associated complex. Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10064-9. Epub 2005 Jul 7. PMID:16002468 doi:http://dx.doi.org/10.1073/pnas.0504400102
↑ Hundley HA, Walter W, Bairstow S, Craig EA. Human Mpp11 J protein: ribosome-tethered molecular chaperones are ubiquitous. Science. 2005 May 13;308(5724):1032-4. Epub 2005 Mar 31. PMID:15802566 doi:http://dx.doi.org/10.1126/science.1109247
↑ Richly H, Rocha-Viegas L, Ribeiro JD, Demajo S, Gundem G, Lopez-Bigas N, Nakagawa T, Rospert S, Ito T, Di Croce L. Transcriptional activation of polycomb-repressed genes by ZRF1. Nature. 2010 Dec 23;468(7327):1124-8. doi: 10.1038/nature09574. PMID:21179169 doi:http://dx.doi.org/10.1038/nature09574

1 Structural highlights
2 Function
3 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2m2e"

@@ Line 2: / Line 2: @@
 <StructureSection load='2m2e' size='340' side='right' caption='[[2m2e]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2m2e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M2E FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2m2e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M2E FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DNAJC2, MPHOSPH11, MPP11, ZRF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DNAJC2, MPHOSPH11, MPP11, ZRF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m2e RCSB], [http://www.ebi.ac.uk/pdbsum/2m2e PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2e OCA], [http://pdbe.org/2m2e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m2e RCSB], [http://www.ebi.ac.uk/pdbsum/2m2e PDBsum]</span></td></tr>
 </table>
 == Function ==
@@ Line 12: / Line 12: @@
 __TOC__
 </StructureSection>
-[[Category: Homo sapiens]]
+[[Category: Human]]
 [[Category: Arrowsmith, C]]
 [[Category: Garcia, M]]

2m2e

From Proteopedia

Revision as of 22:12, 11 September 2015

Solution NMR structure of the SANT domain of human DNAJC2, Northeast structural genomics consortium target HR8254a

Structural highlights

Function

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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