2ba2

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|ACTIVITY=
|ACTIVITY=
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam01519 DUF16]</span>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ba2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ba2 OCA], [http://www.ebi.ac.uk/pdbsum/2ba2 PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=2ba2 RCSB]</span>
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[[Category: stutter]]
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Revision as of 04:22, 26 March 2008

Image:2ba2.gif


PDB ID 2ba2

Drag the structure with the mouse to rotate
, resolution 1.80Å
Domains: DUF16
Resources: FirstGlance, OCA, PDBsum, JenaLib, RCSB
Coordinates: save as pdb, mmCIF, xml



Crystal structure of the DUF16 domain of MPN010 from Mycoplasma pneumoniae


Overview

We have determined the crystal structure of the DUF16 domain of unknown function encoded by the gene MPN010 of Mycoplasma pneumoniae at 1.8 A resolution. The crystal structure revealed that this domain is composed of two separated homotrimeric coiled-coils. The shorter one consists of 11 highly conserved residues. The sequence comprises noncanonical heptad repeats that induce a right-handed coiled-coil structure. The longer one is composed of approximately nine heptad repeats. In this coiled-coil structure, there are three distinguishable regions that confer unique structural properties compared with other known homotrimeric coiled-coils. The first part, containing one stutter, is an unusual phenylalanine-rich region that is not found in any other coiled-coil structures. The second part is a highly conserved glutamine-rich region, frequently found in other trimeric coiled-coil structures. The last part is composed of prototype heptad repeats. The phylogenetic analysis of the DUF16 family together with a secondary structure prediction shows that the DUF16 family can be classified into five subclasses according to N-terminal sequences. Based on the structural comparison with other coiled-coil structures, a probable molecular function of the DUF16 family is discussed.

About this Structure

2BA2 is a Single protein structure of sequence from Mycoplasma pneumoniae. Full crystallographic information is available from OCA.

Reference

Crystal structure of the DUF16 domain of MPN010 from Mycoplasma pneumoniae., Shin DH, Kim JS, Yokota H, Kim R, Kim SH, Protein Sci. 2006 Apr;15(4):921-8. Epub 2006 Mar 7. PMID:16522803

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