1vc8
From Proteopedia
(Difference between revisions)
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<StructureSection load='1vc8' size='340' side='right' caption='[[1vc8]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='1vc8' size='340' side='right' caption='[[1vc8]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1vc8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1vc8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VC8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VC8 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5FA:ADENOSINE-5-PENTAPHOSPHATE'>5FA</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5FA:ADENOSINE-5-PENTAPHOSPHATE'>5FA</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1vc9|1vc9]], [[1vcd|1vcd]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1vc9|1vc9]], [[1vcd|1vcd]]</td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ndx1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ndx1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 THET8])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vc8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vc8 RCSB], [http://www.ebi.ac.uk/pdbsum/1vc8 PDBsum], [http://www.topsan.org/Proteins/RSGI/1vc8 TOPSAN]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vc8 OCA], [http://pdbe.org/1vc8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vc8 RCSB], [http://www.ebi.ac.uk/pdbsum/1vc8 PDBsum], [http://www.topsan.org/Proteins/RSGI/1vc8 TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/ | + | [[http://www.uniprot.org/uniprot/NDX1_THETH NDX1_THETH]] Specifically hydrolyzes (di)adenosine polyphosphates but not ATP or diadenosine triphosphate, generating ATP as the product. Diadenosine hexaphosphate (Ap6A) is the preferred substrate and its hydrolyzation yields 2 ATP. It is the only enzyme that symmetrically hydrolyzes Ap6A. It also hydrolyzes diadenosine pentaphosphate (Ap5A), diadenosine tetraphosphate (Ap4A), adenosine tetraphosphate (p4A) to produce ATP and ADP, ATP and AMP, ATP and inorganic orthophosphate, respectively.<ref>PMID:15024014</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Thet8]] |
[[Category: Iwai, T]] | [[Category: Iwai, T]] | ||
[[Category: Kuramitsu, S]] | [[Category: Kuramitsu, S]] | ||
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[[Category: Nudix protein]] | [[Category: Nudix protein]] | ||
[[Category: Rsgi]] | [[Category: Rsgi]] | ||
| + | [[Category: Thermus thermophilus hb8]] | ||
Revision as of 01:01, 12 September 2015
Crystal Structure of a T.thermophilus HB8 Ap6A Hydrolase Ndx1-Ap6A Complex
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