2ezd
From Proteopedia
(Difference between revisions)
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<StructureSection load='2ezd' size='340' side='right' caption='[[2ezd]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''> | <StructureSection load='2ezd' size='340' side='right' caption='[[2ezd]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2ezd]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2ezd]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EZD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EZD FirstGlance]. <br> |
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2eze|2eze]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2eze|2eze]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ezd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ezd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ezd RCSB], [http://www.ebi.ac.uk/pdbsum/2ezd PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ezd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ezd OCA], [http://pdbe.org/2ezd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ezd RCSB], [http://www.ebi.ac.uk/pdbsum/2ezd PDBsum]</span></td></tr> |
</table> | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/HMGA1_HUMAN HMGA1_HUMAN]] A chromosomal aberration involving HMGA1 is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23-24) with RAD51B. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HMGA1_HUMAN HMGA1_HUMAN]] HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2ezd" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
*[[HMGI(Y)|HMGI(Y)]] | *[[HMGI(Y)|HMGI(Y)]] | ||
| + | *[[High mobility group protein|High mobility group protein]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Human]] |
[[Category: Bewley, C]] | [[Category: Bewley, C]] | ||
[[Category: Clore, G M]] | [[Category: Clore, G M]] | ||
Revision as of 02:41, 12 September 2015
SOLUTION STRUCTURE OF A COMPLEX OF THE SECOND DNA BINDING DOMAIN OF HUMAN HMG-I(Y) BOUND TO DNA DODECAMER CONTAINING THE PRDII SITE OF THE INTERFERON-BETA PROMOTER, NMR, MINIMIZED AVERAGE STRUCTURE
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