NADP-dependent malic enzyme

Best example is PDB entry 1swy and is shown in the viewer.

Molecule Lysozyme, also known as Lysozyme, CP-7 lysin, Muramidase, Endolysin, 1,4-beta-N-acetylmuramidase, Lysis protein, CP-1 lysin, Lysozyme murein hydrolase, Protein gp17, Transglycosylase, Hevamine-A, Chitinase and L-alanyl-D-glutamate peptidase.

Function

Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.Data source: Uniprot P00720

Catalytic Activity

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.Data source: Uniprot P00720

Disease

Relevance

Structural highlights

Biological process

Is involved in the following biological processes:
cell wall macromolecule catabolic process
peptidoglycan catabolic process
metabolic process
defense response to bacterium
cytolysis
viral release from host cell
carbohydrate metabolic process
chitin catabolic process
polysaccharide catabolic process
cytolysis by virus of host cell
cell wall organization

In structures

Lysozyme is found in 595 PDB entries

• Viruses (578 PDB entries):
  
  • Enterobacteria phage T4 (561 PDB entries):
    
    • 1swy
    • Title: Use of a Halide Binding Site to Bypass the 1000-atom Limit to Ab initio Structure Determination
    • 1.06 A resolution
    • Search for other PDB entries
  • Streptococcus phage Cp-1 (6 PDB entries):
    
    • 2j8g
    • Title: Crystal structure of the modular Cpl-1 endolysin complexed with a peptidoglycan analogue (E94Q mutant in complex with a tetrasaccharide- pentapeptide)
    • 1.69 A resolution
    • Search for other PDB entries
  • Enterobacteria phage lambda (3 PDB entries):
    
    • 1am7
    • Title: Lysozyme from bacteriophage lambda
    • 2.3 A resolution
    • Search for other PDB entries
  • Enterobacteria phage P1 (2 PDB entries):
    
    • 1xju
    • Title: Crystal structure of secreted inactive form of P1 phage endolysin Lyz
    • 1.07 A resolution
    • Search for other PDB entries
  • Streptococcus phage CP-7 (1 PDB entries):
    
    • 4cvd
    • Title: Crystal structure of the central repeat of cell wall binding module of Cpl7
    • 1.666 A resolution
• Eukaryota (16 PDB entries):
  
  • Hevea brasiliensis (7 PDB entries):
    
    • 1kqy
    • Title: Hevamine Mutant D125A/E127A/Y183F in Complex with Penta-NAG
    • 1.92 A resolution
    • Search for other PDB entries
  • Meretrix lusoria (3 PDB entries):
    
    • 4pj2
    • Title: Crystal structure of Aeromonas hydrophila PliI in complex with Meretrix lusoria lysozyme
    • 1.24 A resolution
    • Other macromolecules also in this entry: Putative exported protein, .
    • Search for other PDB entries
  • Bombyx mori (2 PDB entries):
    
    • 1gd6
    • Title: STRUCTURE OF THE BOMBYX MORI LYSOZYME
    • 2.5 A resolution
    • Search for other PDB entries
  • Mus musculus (1 PDB entries):
    
    • 1iak
    • Title: HISTOCOMPATIBILITY ANTIGEN I-AK
    • 1.9 A resolution
    • Other macromolecules also in this entry: H-2 class II histocompatibility antigen, A-K beta chain, H-2 class II histocompatibility antigen, A-K alpha chain.
• Bacteria (1 PDB entries):
  
  • Escherichia coli (1 PDB entries):
    
    • 2qb0
    • Title: Structure of the 2TEL crystallization module fused to T4 lysozyme with an Ala-Gly-Pro linker.
    • 2.56 A resolution
    • Other macromolecules also in this entry: Transcription factor ETV6, .