Beta-secretase 1

Best example is PDB entry 4ivt and is shown in the viewer.

Molecule Beta-secretase 1, also known as Beta-site amyloid precursor protein cleaving enzyme 1, Membrane-associated aspartic protease 2, Aspartyl protease 2, Asp 2, ASP2, Memapsin-2, Beta-secretase 1 and Beta-site APP cleaving enzyme 1.

Function

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.Data source: Uniprot P56817

Catalytic Activity

Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer amyloid precursor protein.Data source: Uniprot P56817

Disease

Relevance

Structural highlights

Biological process

Is involved in the following biological processes:
proteolysis

In structures

Beta-secretase 1 is found in 326 PDB entries

• Eukaryota (323 PDB entries):
  
  • Homo sapiens (324 PDB entries):
    
    • 4ivt
    • Title: Crystal structure of BACE1 with its inhibitor
    • 1.6 A resolution
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