DNA polymerase beta

Best example is PDB entry 2fmp and is shown in the viewer.

Molecule DNA polymerase beta, also known as and DNA polymerase beta.

Function

Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.Data source: Uniprot P06746

Catalytic Activity

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).Data source: Uniprot P06746

Disease

Relevance

Structural highlights

Biological process

Is involved in the following biological processes:
DNA repair
DNA biosynthetic process
immunoglobulin heavy chain V-D-J recombination
response to gamma radiation
DNA replication
homeostasis of number of cells
spleen development
neuron apoptotic process
base-excision repair, gap-filling
base-excision repair
lymph node development
salivary gland morphogenesis
response to ethanol
aging
response to hyperoxia
somatic diversification of immunoglobulins
cellular response to DNA damage stimulus
inflammatory response
apoptotic process
somatic hypermutation of immunoglobulin genes
pyrimidine dimer repair
intrinsic apoptotic signaling pathway in response to DNA damage
DNA-dependent DNA replication
nucleotide-excision repair, DNA gap filling

In structures

DNA polymerase beta is found in 264 PDB entries

• Eukaryota (264 PDB entries):
  
  • Homo sapiens (230 PDB entries):
    
    • 2fmp
    • Title: DNA Polymerase beta with a terminated gapped DNA substrate and ddCTP with sodium in the catalytic site
    • 1.65 A resolution
    • Other macromolecules also in this entry: 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', 5'-D(P*GP*TP*CP*GP*G)-3', 5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'.
    • Search for other PDB entries
  • Rattus norvegicus (31 PDB entries):
    
    • 3lqc
    • Title: X-ray crystal structure of oxidized XRCC1 bound to DNA pol beta Palm thumb domain
    • 2.349 A resolution
    • Other macromolecules also in this entry: DNA repair protein XRCC1..
    • Search for other PDB entries
  • Leishmania infantum (3 PDB entries):
    
    • 4p4m
    • Title: Crystal structure of Leishmania infantum polymerase beta: Ternary P/T complex
    • 1.9185 A resolution
    • Other macromolecules also in this entry: DNA (5'-D(*CP*AP*GP*TP*A)-3'), DNA (5'-D(P*AP*TP*AP*CP*TP*G)-3').
    • Search for other PDB entries