2hek
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 2hek |SIZE=350|CAPTION= <scene name='initialview01'>2hek</scene>, resolution 1.997Å | |PDB= 2hek |SIZE=350|CAPTION= <scene name='initialview01'>2hek</scene>, resolution 1.997Å | ||
|SITE= <scene name='pdbsite=AC1:Po4+Binding+Site+For+Residue+A+501'>AC1</scene>, <scene name='pdbsite=AC2:Po4+Binding+Site+For+Residue+B+502'>AC2</scene>, <scene name='pdbsite=AC3:Po4+Binding+Site+For+Residue+B+503'>AC3</scene>, <scene name='pdbsite=AC4:Po4+Binding+Site+For+Residue+B+504'>AC4</scene>, <scene name='pdbsite=AC5:Zn+Binding+Site+For+Residue+B+601'>AC5</scene>, <scene name='pdbsite=AC6:Zn+Binding+Site+For+Residue+A+602'>AC6</scene>, <scene name='pdbsite=AC7:Br+Binding+Site+For+Residue+B+603'>AC7</scene>, <scene name='pdbsite=AC8:Cl+Binding+Site+For+Residue+A+604'>AC8</scene>, <scene name='pdbsite=AC9:Cl+Binding+Site+For+Residue+B+605'>AC9</scene>, <scene name='pdbsite=BC1:Cl+Binding+Site+For+Residue+A+606'>BC1</scene>, <scene name='pdbsite=BC2:Cl+Binding+Site+For+Residue+B+607'>BC2</scene>, <scene name='pdbsite=BC3:Cl+Binding+Site+For+Residue+B+608'>BC3</scene>, <scene name='pdbsite=BC4:Gdp+Binding+Site+For+Residue+A+401'>BC4</scene>, <scene name='pdbsite=BC5:Gdp+Binding+Site+For+Residue+A+402'>BC5</scene>, <scene name='pdbsite=BC6:Gol+Binding+Site+For+Residue+A+403'>BC6</scene>, <scene name='pdbsite=BC7:Gol+Binding+Site+For+Residue+A+404'>BC7</scene>, <scene name='pdbsite=BC8:Gol+Binding+Site+For+Residue+B+405'>BC8</scene>, <scene name='pdbsite=BC9:Gol+Binding+Site+For+Residue+A+406'>BC9</scene>, <scene name='pdbsite=CC1:Gol+Binding+Site+For+Residue+A+407'>CC1</scene>, <scene name='pdbsite=CC2:Gol+Binding+Site+For+Residue+A+408'>CC2</scene>, <scene name='pdbsite=CC3:Gol+Binding+Site+For+Residue+B+409'>CC3</scene> and <scene name='pdbsite=CC4:Gol+Binding+Site+For+Residue+A+410'>CC4</scene> | |SITE= <scene name='pdbsite=AC1:Po4+Binding+Site+For+Residue+A+501'>AC1</scene>, <scene name='pdbsite=AC2:Po4+Binding+Site+For+Residue+B+502'>AC2</scene>, <scene name='pdbsite=AC3:Po4+Binding+Site+For+Residue+B+503'>AC3</scene>, <scene name='pdbsite=AC4:Po4+Binding+Site+For+Residue+B+504'>AC4</scene>, <scene name='pdbsite=AC5:Zn+Binding+Site+For+Residue+B+601'>AC5</scene>, <scene name='pdbsite=AC6:Zn+Binding+Site+For+Residue+A+602'>AC6</scene>, <scene name='pdbsite=AC7:Br+Binding+Site+For+Residue+B+603'>AC7</scene>, <scene name='pdbsite=AC8:Cl+Binding+Site+For+Residue+A+604'>AC8</scene>, <scene name='pdbsite=AC9:Cl+Binding+Site+For+Residue+B+605'>AC9</scene>, <scene name='pdbsite=BC1:Cl+Binding+Site+For+Residue+A+606'>BC1</scene>, <scene name='pdbsite=BC2:Cl+Binding+Site+For+Residue+B+607'>BC2</scene>, <scene name='pdbsite=BC3:Cl+Binding+Site+For+Residue+B+608'>BC3</scene>, <scene name='pdbsite=BC4:Gdp+Binding+Site+For+Residue+A+401'>BC4</scene>, <scene name='pdbsite=BC5:Gdp+Binding+Site+For+Residue+A+402'>BC5</scene>, <scene name='pdbsite=BC6:Gol+Binding+Site+For+Residue+A+403'>BC6</scene>, <scene name='pdbsite=BC7:Gol+Binding+Site+For+Residue+A+404'>BC7</scene>, <scene name='pdbsite=BC8:Gol+Binding+Site+For+Residue+B+405'>BC8</scene>, <scene name='pdbsite=BC9:Gol+Binding+Site+For+Residue+A+406'>BC9</scene>, <scene name='pdbsite=CC1:Gol+Binding+Site+For+Residue+A+407'>CC1</scene>, <scene name='pdbsite=CC2:Gol+Binding+Site+For+Residue+A+408'>CC2</scene>, <scene name='pdbsite=CC3:Gol+Binding+Site+For+Residue+B+409'>CC3</scene> and <scene name='pdbsite=CC4:Gol+Binding+Site+For+Residue+A+410'>CC4</scene> | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GDP:GUANOSINE-5'-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00077 HDc], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1078 COG1078]</span> | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hek FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hek OCA], [http://www.ebi.ac.uk/pdbsum/2hek PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=2hek RCSB]</span> | ||
}} | }} | ||
| Line 28: | Line 30: | ||
[[Category: Kim, S H.]] | [[Category: Kim, S H.]] | ||
[[Category: Oganesyan, V.]] | [[Category: Oganesyan, V.]] | ||
| - | [[Category: BR]] | ||
| - | [[Category: CL]] | ||
| - | [[Category: GDP]] | ||
| - | [[Category: GOL]] | ||
| - | [[Category: PO4]] | ||
| - | [[Category: ZN]] | ||
[[Category: berkeley structural genomics center]] | [[Category: berkeley structural genomics center]] | ||
[[Category: bsgc]] | [[Category: bsgc]] | ||
| Line 42: | Line 38: | ||
[[Category: unknown function]] | [[Category: unknown function]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 06:28:42 2008'' |
Revision as of 04:28, 26 March 2008
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| , resolution 1.997Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | , , , , , , , , , , , , , , , , , , , , and | ||||||
| Ligands: | , , , , , | ||||||
| Domains: | HDc, COG1078 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, JenaLib, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of O67745, a hypothetical protein from Aquifex aeolicus at 2.0 A resolution.
Overview
Using single-wavelength anomalous dispersion data obtained from a gold-derivatized crystal, the X-ray crystal structure of the protein 067745_AQUAE from the prokaryotic organism Aquifex aeolicus has been determined to a resolution of 2.0 A. Amino-acid residues 1-371 of the 44 kDa protein were identified by Pfam as an HD domain and a member of the metal-dependent phosphohydrolase superfamily (accession No. PF01966). Although three families from this large and diverse group of enzymatic proteins are represented in the PDB, the structure of 067745_AQUAE reveals a unique fold that is unlike the others and that is likely to represent a new subfamily, further organizing the families and characterizing the proteins. Data are presented that provide the first insights into the structural organization of the proteins within this clan and a distal alternative GDP-binding domain outside the metal-binding active site is proposed.
About this Structure
2HEK is a Single protein structure of sequence from Aquifex aeolicus. Full crystallographic information is available from OCA.
Reference
Structure of O67745_AQUAE, a hypothetical protein from Aquifex aeolicus., Oganesyan V, Adams PD, Jancarik J, Kim R, Kim SH, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 May 1;63(Pt, 5):369-74. Epub 2007 Apr 28. PMID:17565173
Page seeded by OCA on Wed Mar 26 06:28:42 2008
Categories: Aquifex aeolicus | Single protein | Adams, P D. | BSGC, Berkeley Structural Genomics Center. | Jancarik, J. | Kim, R. | Kim, S H. | Oganesyan, V. | Berkeley structural genomics center | Bsgc | Predominantly alpha helical protein with gdp binding site and active site being far from each other | Protein structure initiative | Psi | Structural genomic | Unknown function
