4uy9

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'''Unreleased structure'''
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==Structure of MLK1 kinase domain with leucine zipper 1==
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<StructureSection load='4uy9' size='340' side='right' caption='[[4uy9]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
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The entry 4uy9 is ON HOLD
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4uy9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UY9 FirstGlance]. <br>
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Authors: READ, J.A., BRASSINGTON, C., POLLARD, H.K., PHILLIPS, C., GREEN, I., OVERMANN, R., COLLIER, M.
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uya|4uya]]</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase_kinase_kinase Mitogen-activated protein kinase kinase kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.25 2.7.11.25] </span></td></tr>
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Description: Structure of MLK1 kinase domain with leucine zipper 1
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uy9 OCA], [http://pdbe.org/4uy9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uy9 RCSB], [http://www.ebi.ac.uk/pdbsum/4uy9 PDBsum]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Overmann, R]]
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== Disease ==
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[[http://www.uniprot.org/uniprot/M3K9_HUMAN M3K9_HUMAN]] May play a role in esophageal cancer susceptibility and/or development.
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== Function ==
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[[http://www.uniprot.org/uniprot/M3K9_HUMAN M3K9_HUMAN]] Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.<ref>PMID:15610029</ref> <ref>PMID:11416147</ref> <ref>PMID:18241037</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Mitogen-activated protein kinase kinase kinase]]
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[[Category: Brassington, C]]
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[[Category: Collier, M]]
[[Category: Green, I]]
[[Category: Green, I]]
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[[Category: Read, J.A]]
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[[Category: Overmann, R]]
[[Category: Phillips, C]]
[[Category: Phillips, C]]
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[[Category: Pollard, H.K]]
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[[Category: Pollard, H K]]
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[[Category: Collier, M]]
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[[Category: Read, J A]]
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[[Category: Brassington, C]]
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[[Category: Atp-binding]]
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[[Category: Kinase]]
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[[Category: Mlk family]]
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[[Category: Mlk1 and mlk3 subtype]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphoprotein]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Sh3 domain]]
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[[Category: Transferase]]

Revision as of 14:39, 30 September 2015

Structure of MLK1 kinase domain with leucine zipper 1

4uy9, resolution 2.81Å

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