4uya
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Structure of MLK4 kinase domain with ATPgammaS== |
| - | + | <StructureSection load='4uya' size='340' side='right' caption='[[4uya]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4uya]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UYA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UYA FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uy9|4uy9]]</td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase_kinase_kinase Mitogen-activated protein kinase kinase kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.25 2.7.11.25] </span></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uya OCA], [http://pdbe.org/4uya PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uya RCSB], [http://www.ebi.ac.uk/pdbsum/4uya PDBsum]</span></td></tr> |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/M3KL4_HUMAN M3KL4_HUMAN]] Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.<ref>PMID:21602844</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Mitogen-activated protein kinase kinase kinase]] | ||
| + | [[Category: Brassington, C]] | ||
| + | [[Category: Collier, M]] | ||
[[Category: Green, I]] | [[Category: Green, I]] | ||
| - | [[Category: | + | [[Category: Overmann, R]] |
[[Category: Phillips, C]] | [[Category: Phillips, C]] | ||
| - | [[Category: Pollard, H | + | [[Category: Pollard, H K]] |
| - | [[Category: | + | [[Category: Read, J A]] |
| - | [[Category: | + | [[Category: Atp-binding]] |
| + | [[Category: Leucine zipper 1]] | ||
| + | [[Category: Mixed-lineage kinase]] | ||
| + | [[Category: Nucleotide-binding]] | ||
| + | [[Category: Phosphoprotein]] | ||
| + | [[Category: Serine/threonine-protein kinase]] | ||
| + | [[Category: Sh3 domain]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 14:39, 30 September 2015
Structure of MLK4 kinase domain with ATPgammaS
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Categories: Mitogen-activated protein kinase kinase kinase | Brassington, C | Collier, M | Green, I | Overmann, R | Phillips, C | Pollard, H K | Read, J A | Atp-binding | Leucine zipper 1 | Mixed-lineage kinase | Nucleotide-binding | Phosphoprotein | Serine/threonine-protein kinase | Sh3 domain | Transferase
