This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4yfz
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | ''' | + | ==Structural basis of glycan recognition in neonate-specific rotaviruses== |
| - | + | <StructureSection load='4yfz' size='340' side='right' caption='[[4yfz]], [[Resolution|resolution]] 1.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4yfz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YFZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YFZ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4yfw|4yfw]], [[4ye2|4ye2]], [[4yg0|4yg0]], [[4yg3|4yg3]], [[4yg6|4yg6]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yfz OCA], [http://pdbe.org/4yfz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yfz RCSB], [http://www.ebi.ac.uk/pdbsum/4yfz PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/B6RGK2_9REOV B6RGK2_9REOV]] Outer capsid protein VP5*: forms the spike "foot" and "body". Acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm. In integrin-dependent strains, VP5* targets the integrin heterodimer ITGA2/ITGB1 for cell attachment (By similarity).[SAAS:SAAS00209906] VP8* forms the head of the spikes. It is the viral hemagglutinin and an important target of neutralizing antibodies. In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact (By similarity).[SAAS:SAAS00209911] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Hu, L]] | [[Category: Hu, L]] | ||
| - | [[Category: Prasad, B | + | [[Category: Prasad, B V.V]] |
| + | [[Category: Glycan]] | ||
| + | [[Category: Rotavirus]] | ||
| + | [[Category: Structural biology]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 14:41, 30 September 2015
Structural basis of glycan recognition in neonate-specific rotaviruses
| |||||||||||
