4yg0
From Proteopedia
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| - | ''' | + | ==Structural basis of glycan recognition in neonate-specific rotaviruses== |
| - | + | <StructureSection load='4yg0' size='340' side='right' caption='[[4yg0]], [[Resolution|resolution]] 1.28Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4yg0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YG0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YG0 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4yfz|4yfz]], [[4ye2|4ye2]], [[4yfw|4yfw]], [[4yg3|4yg3]], [[4yg6|4yg6]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yg0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yg0 OCA], [http://pdbe.org/4yg0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yg0 RCSB], [http://www.ebi.ac.uk/pdbsum/4yg0 PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/B6RGK2_9REOV B6RGK2_9REOV]] Outer capsid protein VP5*: forms the spike "foot" and "body". Acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm. In integrin-dependent strains, VP5* targets the integrin heterodimer ITGA2/ITGB1 for cell attachment (By similarity).[SAAS:SAAS00209906] VP8* forms the head of the spikes. It is the viral hemagglutinin and an important target of neutralizing antibodies. In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact (By similarity).[SAAS:SAAS00209911] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Hu, L]] | [[Category: Hu, L]] | ||
| - | [[Category: Prasad, B | + | [[Category: Prasad, B V.V]] |
| + | [[Category: Glycan]] | ||
| + | [[Category: Rotavirus]] | ||
| + | [[Category: Structural biology]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 14:41, 30 September 2015
Structural basis of glycan recognition in neonate-specific rotaviruses
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