Ivan Koutsopatriy estrogen receptor
From Proteopedia
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<scene name='71/714947/Agonist_estradiol_bound_er/1'>Agonist_estradiol_bound_er</scene> | <scene name='71/714947/Agonist_estradiol_bound_er/1'>Agonist_estradiol_bound_er</scene> | ||
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| + | The specific conformation of this tight loop creates part of the activation signal that will stimulate normal growth, as estradiol is a normal ligand for ER. | ||
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| + | <scene name='71/714947/Antagonist_tamoxifen_bound_er/1'>Antagonist_tamoxifen_bound_er</scene> | ||
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| + | Tamoxifen is a drug created to bind ER and inhibit the transcription factor. Tamoxifen is larger than the hormone and for this reason the activation loop is pushed into an inactive conformation. This blocks ER from giving the signal to grow. | ||
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
Revision as of 13:13, 6 October 2015
Your Heading Here (maybe something like 'Structure')
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
