4zkh
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zkh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zkh OCA], [http://pdbe.org/4zkh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zkh RCSB], [http://www.ebi.ac.uk/pdbsum/4zkh PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zkh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zkh OCA], [http://pdbe.org/4zkh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zkh RCSB], [http://www.ebi.ac.uk/pdbsum/4zkh PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Ferritin from the marine pennate diatom Pseudo-nitzschia multiseries (PmFTN) plays a key role in sustaining growth in iron-limited ocean environments. The di-iron catalytic ferroxidase center of PmFTN (sites A and B) has a nearby third iron site (site C) in an arrangement typically observed in prokaryotic ferritins. Here we demonstrate that Glu44, a site C ligand, and Glu130, a residue that bridges iron bound at sites B and C, limit the rate of post-oxidation reorganization of iron coordination and the rate at which Fe3+ exits the ferroxidase center for storage within the mineral core. The latter, in particular, severely limits the overall rate of iron mineralization. Thus, the diatom ferritin is optimized for initial Fe2+ oxidation but not for mineralization, pointing to a role for this protein in buffering iron availability and facilitating iron-sparing rather than only long-term iron storage. | ||
| + | |||
| + | A Diatom Ferritin Optimized for Iron Oxidation but not Iron Storage.,Pfaffen S, Bradley JM, Abdulqadir R, Firme MR, Moore GR, Le Brun NE, Murphy ME J Biol Chem. 2015 Sep 22. pii: jbc.M115.669713. PMID:26396187<ref>PMID:26396187</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 4zkh" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 07:43, 7 October 2015
Crystal structure of the PmFTN variant E44Q soaked in iron (overnight)
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