4rta
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Cystal structure of the Dpy30 for MLL/SET1 COMPASS H3K4 trimethylation== |
| - | + | <StructureSection load='4rta' size='340' side='right' caption='[[4rta]], [[Resolution|resolution]] 2.12Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4rta]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RTA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RTA FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rta FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rta OCA], [http://pdbe.org/4rta PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rta RCSB], [http://www.ebi.ac.uk/pdbsum/4rta PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[ | + | == Function == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/DPY30_HUMAN DPY30_HUMAN]] As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport.<ref>PMID:19556245</ref> <ref>PMID:19651892</ref> <ref>PMID:21335234</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Chang, W R]] | ||
[[Category: Li, M]] | [[Category: Li, M]] | ||
| - | [[Category: | + | [[Category: Zhang, H M]] |
| + | [[Category: Ash2l]] | ||
| + | [[Category: H3k4 methylation]] | ||
| + | [[Category: Protein binding]] | ||
| + | [[Category: Rossmann fold]] | ||
Revision as of 13:45, 7 October 2015
Cystal structure of the Dpy30 for MLL/SET1 COMPASS H3K4 trimethylation
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