4q26
From Proteopedia
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| - | ''' | + | ==Crystal Structure of Galectin-1 in Complex with N-Acetyllactosamine== |
| - | + | <StructureSection load='4q26' size='340' side='right' caption='[[4q26]], [[Resolution|resolution]] 1.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4q26]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q26 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q26 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NLC:2-(ACETYLAMINO)-2-DEOXY-4-O-BETA-D-GALACTOPYRANOSYL-ALPHA-D-GLUCOPYRANOSE'>NLC</scene></td></tr> | |
| - | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4q1p|4q1p]], [[4q1r|4q1r]], [[4q27|4q27]], [[4q2f|4q2f]]</td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q26 OCA], [http://pdbe.org/4q26 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q26 RCSB], [http://www.ebi.ac.uk/pdbsum/4q26 PDBsum]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/LEG1_HUMAN LEG1_HUMAN]] May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.<ref>PMID:14617626</ref> <ref>PMID:18796645</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Bertleff-Zieschang, N]] | [[Category: Bertleff-Zieschang, N]] | ||
[[Category: Grimm, C]] | [[Category: Grimm, C]] | ||
| + | [[Category: Sugar binding protein]] | ||
Revision as of 13:48, 7 October 2015
Crystal Structure of Galectin-1 in Complex with N-Acetyllactosamine
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