2cji
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | 2CJI is a | + | 2CJI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA and GSK as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] Structure known Active Site: AC1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CJI OCA]. |
==Reference== | ==Reference== | ||
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[[Category: zymogen]] | [[Category: zymogen]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 14:56:17 2007'' |
Revision as of 12:50, 5 November 2007
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CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX
Overview
A series of novel, non-basic, 3-(6-chloronaphth-2-ylsulfonyl)aminopyrrolidin-2-one-based factor Xa (fXa), inhibitors, incorporating an alanylamide P4 group, was designed and, synthesised. Within this series, the N-2-(morpholin-4-yl)-2-oxoethyl, derivative 24 was shown to be a potent, selective fXa inhibitor with good, anticoagulant activity. Moreover, 24 possessed highly encouraging rat and, dog pharmacokinetic profiles with excellent oral bioavailabilities in both, species.
About this Structure
2CJI is a Single protein structure of sequence from Homo sapiens with CA and GSK as ligands. Active as Coagulation factor Xa, with EC number 3.4.21.6 Structure known Active Site: AC1. Full crystallographic information is available from OCA.
Reference
Design and synthesis of orally active pyrrolidin-2-one-based factor Xa inhibitors., Watson NS, Brown D, Campbell M, Chan C, Chaudry L, Convery MA, Fenwick R, Hamblin JN, Haslam C, Kelly HA, King NP, Kurtis CL, Leach AR, Manchee GR, Mason AM, Mitchell C, Patel C, Patel VK, Senger S, Shah GP, Weston HE, Whitworth C, Young RJ, Bioorg Med Chem Lett. 2006 Jul 15;16(14):3784-8. Epub 2006 May 11. PMID:16697194
Page seeded by OCA on Mon Nov 5 14:56:17 2007
Categories: Coagulation factor Xa | Homo sapiens | Single protein | Campbell, M. | Chan, C. | Convery, M.A. | Hamblin, J.N. | Kelly, H.A. | King, N.P. | Mason, A.M. | Mitchell, C. | Patel, V.K. | Senger, S. | Shah, G.P. | Watson, N.S. | Weston, H.E. | Whitworth, C. | Young, R.J. | CA | GSK | Blood coagulation | Calcium | Egf-like domain | Gamma-carboxyglutamic acid | Glycoprotein | Hydrolase | Hydroxylation | Polymorphism | Protease | Serine protease | Zymogen
