4rz4

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'''Unreleased structure'''
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==Fructose-6-phosphate aldolase Q59E Y131F from E.coli==
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<StructureSection load='4rz4' size='340' side='right' caption='[[4rz4]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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The entry 4rz4 is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4rz4]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RZ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RZ4 FirstGlance]. <br>
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Authors: Sandalova, T., Stellmacher, L., Leptihn, S., Schneider, G., Sprenger, G.A., Samland, A.K.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rz4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rz4 OCA], [http://pdbe.org/4rz4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rz4 RCSB], [http://www.ebi.ac.uk/pdbsum/4rz4 PDBsum]</span></td></tr>
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Description: Fructose-6-phosphate aldolase Q59E Y131F from E.coli
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</table>
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[[Category: Unreleased Structures]]
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== Function ==
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[[http://www.uniprot.org/uniprot/FSAA_ECOLI FSAA_ECOLI]] Catalyzes the reversible formation of fructose 6-phosphate from dihydroxyacetone (DHA) and D-glyceraldehyde 3-phosphate via an aldolization reaction. Can utilize several aldehydes as acceptor compounds in vitro, and hydroxyacetone (HA) or 1-hydroxy-butan-2-one as alternative donor substrate. Is also able to catalyze the direct stereoselective self-aldol addition of glycolaldehyde to furnish D-(-)-threose, and cross-aldol reactions of glycolaldehyde to other aldehyde acceptors. Is not able to cleave fructose, fructose 1-phosphate, glucose 6-phosphate, sedoheptulose 1,7-bisphosphate, xylulose 5-phosphate, ribulose 5-phosphate, and fructose 1,6-bisphosphate; cannot use dihydroxyacetone phosphate as donor compound nor D-glyceraldehyde as acceptor. Does not display transaldolase activity.<ref>PMID:11120740</ref> [HAMAP-Rule:MF_00496]<ref>PMID:17985886</ref> <ref>PMID:19554584</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Leptihn, S]]
[[Category: Leptihn, S]]
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[[Category: Samland, A.K]]
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[[Category: Samland, A K]]
[[Category: Sandalova, T]]
[[Category: Sandalova, T]]
[[Category: Schneider, G]]
[[Category: Schneider, G]]
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[[Category: Sprenger, G.A]]
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[[Category: Sprenger, G A]]
[[Category: Stellmacher, L]]
[[Category: Stellmacher, L]]
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[[Category: Homodecamer]]
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[[Category: Lyase]]
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[[Category: Tim barrel]]

Revision as of 13:48, 7 October 2015

Fructose-6-phosphate aldolase Q59E Y131F from E.coli

4rz4, resolution 1.75Å

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