5crd
From Proteopedia
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| - | ''' | + | ==Wild-type human skeletal calsequestrin== |
| - | + | <StructureSection load='5crd' size='340' side='right' caption='[[5crd]], [[Resolution|resolution]] 2.08Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5crd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CRD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CRD FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5crd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5crd OCA], [http://pdbe.org/5crd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5crd RCSB], [http://www.ebi.ac.uk/pdbsum/5crd PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[ | + | == Function == |
| - | [[ | + | [[http://www.uniprot.org/uniprot/CASQ1_HUMAN CASQ1_HUMAN]] Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction.<ref>PMID:22337878</ref> <ref>PMID:22337878</ref> |
| - | [[ | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Kang, C]] | [[Category: Kang, C]] | ||
| + | [[Category: Lewis, K M]] | ||
| + | [[Category: Ronish, L A]] | ||
| + | [[Category: Calcium binding protein]] | ||
Revision as of 13:52, 7 October 2015
Wild-type human skeletal calsequestrin
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