5cre
From Proteopedia
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| - | ''' | + | ==Human skeletal calsequestrin, D210G mutant low-calcium complex== |
| - | + | <StructureSection load='5cre' size='340' side='right' caption='[[5cre]], [[Resolution|resolution]] 3.31Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5cre]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CRE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CRE FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5crh|5crh]], [[5crd|5crd]], [[5crg|5crg]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cre OCA], [http://pdbe.org/5cre PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cre RCSB], [http://www.ebi.ac.uk/pdbsum/5cre PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[ | + | == Function == |
| - | [[ | + | [[http://www.uniprot.org/uniprot/CASQ1_HUMAN CASQ1_HUMAN]] Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction.<ref>PMID:22337878</ref> <ref>PMID:22337878</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Kang, C]] | [[Category: Kang, C]] | ||
| + | [[Category: Lewis, K M]] | ||
| + | [[Category: Ronish, L A]] | ||
| + | [[Category: Calcium binding protein]] | ||
| + | [[Category: Calsequestrin calcium-binding protein]] | ||
Revision as of 13:52, 7 October 2015
Human skeletal calsequestrin, D210G mutant low-calcium complex
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